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An alternative synthesis of the non-small cell lung carcinoma drug afatinib
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-10-15 , DOI: 10.1016/j.tetlet.2018.10.026
Tatjana Kovacevic , Milan Mesic , Amir Avdagic , Miroslav Zegarac

Afatinib (BIBW2992) is the anticancer drug developed by Boehringer Ingelheim. This work is reporting the synthesis of the afatinib using a new route by Ullmann-Goldberg reaction from corresponding 4-anilinoquinazoline iodide as the last step in the synthesis. This route was not described previously and it could be used for synthesis of afatinib analogues.



中文翻译:

非小细胞肺癌药物阿法替尼的另一种合成方法

阿法替尼(BIBW2992)是勃林格殷格翰公司开发的抗癌药物。这项工作报告了通过Ullmann-Goldberg反应从相应的4-苯胺基喹唑啉碘化物通过Ullmann-Goldberg反应的新路线合成afatinib的最后一步。该路线先前未作描述,可用于合成阿法替尼类似物。

更新日期:2018-10-15
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