Electrochemical Study on Quantitative Structure‐activity Relationship (QSAR) Analysis under Steady‐state Conditions,Electroanalysis

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Electrochemical Study on Quantitative Structure‐activity Relationship (QSAR) Analysis under Steady‐state Conditions
Electroanalysis ( IF 2.7 ) Pub Date : 2018-10-15 , DOI: 10.1002/elan.201800351
M. Takaishi ₁ , O. Shirai ₁ , Y. Kitazumi ₁ , K. Kano ₁

Affiliation

The influence of the volume ratio of the aqueous to 1‐octanol phase on drug delivery under steady‐state conditions in a tubular electrolytic cell composed of an organic phase and two aqueous phases was elucidated. Electrochemical measurements on the transport of six quaternary ammonium chlorides were performed using three types of membrane filters of different thickness. The electric resistance of each system was evaluated, and the distribution coefficient of each chloride was estimated from the extraction experiments. The permeation process within the organic phase was the rate‐determining step for tetrapropylammonium, tetrabutylammonium, tetrapentylammonium and tetrahexylammonium chlorides. On the other hand, for tetraoctylammonium chloride, which was the most hydrophobic ion among the six tested, the salt was easily distributed into the organic phase. Therefore, the rate‐determining step changed to the permeation process within the aqueous phase. In addition, the influence of ion‐pair formation on drug delivery was evaluated.

中文翻译：

稳态条件下定量构效关系（QSAR）分析的电化学研究

阐明了在稳态条件下，由有机相和两个水相组成的管状电解池中水与1-辛醇相的体积比对药物输送的影响。使用三种不同厚度的膜滤器对六种氯化季铵盐的迁移进行电化学测量。评估每个系统的电阻，并根据萃取实验估算每种氯化物的分配系数。在有机相中的渗透过程是四丙基铵，四丁基铵，四戊基氯化铵和四己基氯化铵的速率确定步骤。另一方面，对于四辛基氯化铵，它是所测试的六种化合物中疏水性最高的离子，盐很容易分配到有机相中。因此，速率确定步骤更改为在水相中的渗透过程。此外，还评估了离子对形成对药物输送的影响。

更新日期：2018-10-15

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