Carbohydrate‐Based Polymer Brushes Prevent Viral Adsorption on Electrostatically Heterogeneous Interfaces,Macromolecular Rapid Communications

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Carbohydrate‐Based Polymer Brushes Prevent Viral Adsorption on Electrostatically Heterogeneous Interfaces
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2018-10-15 , DOI: 10.1002/marc.201800530
Ramya Kumar _{1,

2} , Domenic Kratzer ₃ , Kenneth Cheng _{2,

4} , Julia Prisby _{2,

5} , James Sugai ₆ , William V. Giannobile ₆ , Joerg Lahann _{1,

2,

4,

5}

Affiliation

Chemical heterogeneity on biomaterial surfaces can transform its interfacial properties, rendering nanoscale heterogeneity profoundly consequential during bioadhesion. To examine the role played by chemical heterogeneity in the adsorption of viruses on synthetic surfaces, a range of novel coatings is developed wherein a tunable mixture of electrostatic tethers for viral binding, and carbohydrate brushes, bearing pendant α‐mannose, β‐galactose, or β‐glucose groups, is incorporated. The effects of binding site density, brush composition, and brush architecture on viral adsorption, with the goal of formulating design specifications for virus‐resistant coatings are experimentally evaluated. It is concluded that virus‐coating interactions are shaped by the interplay between brush architecture and binding site density, after quantifying the adsorption of adenoviruses, influenza, and fibrinogen on a library of carbohydrate brushes co‐immobilized with different ratios of binding sites. These insights will be of utility in guiding the design of polymer coatings in realistic settings where they will be populated with defects.

中文翻译：

基于碳水化合物的聚合物刷可防止病毒在静电异质界面上吸附

生物材料表面上的化学异质性可以改变其界面特性，从而在生物粘附过程中使纳米级异质性产生深远的影响。为了检查化学异质性在合成表面上的病毒吸附中所起的作用，开发了一系列新型涂层，其中可调节静电链的可束缚混合物（用于病毒结合）和碳水化合物刷（带有α-甘露糖，β-半乳糖或侧链） β-葡萄糖基团被并入。以实验方式评估了结合位点密度，刷子成分和刷子结构对病毒吸附的影响，目的是制定抗病毒涂层的设计规范。结论是，病毒涂层的相互作用是由刷子结构和结合位点密度之间的相互作用所决定的，在对腺病毒，流感和纤维蛋白原在固定有不同比例结合位点的糖刷文库上的吸附进行定量后。这些见解将有助于指导实际环境中聚合物涂层的设计，在这些情况下它们将充满缺陷。

更新日期：2018-10-15

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