Spatial confinement of multiple catalysts presents an effective strategy for performing sequential or tandem chemical transformations in a one‐pot reaction. These methods may be used to catalyze numerous reactions in conditions that are otherwise incompatible between catalyst and solvent, different catalysts, or reagents. Appropriate site isolation or support structure design will lead to significant advantages in atom economy, purification, and costs; the development of the interface between a catalyst and its confined microenvironment is paramount for realizing the next generation of nanoreactors. Polymer scaffolds can create tailor‐made microenvironments resulting in catalyst compartmentalization. Through the optimization of a number of variables such as size, solubility, functionality, and morphology of the nanoreactor, catalyst activity and selectivity can be tuned. In this feature article, design principles and early strategies for polymer supports for catalyst site‐isolation are introduced, and current strategies toward multicompartment polymer nanoreactors for non‐orthogonal cascade catalysis are discussed. Future design trends in this burgeoning field are outlined in the conclusion.

中文翻译：

---

用于非正交级联催化的多室聚合物纳米反应器

多种催化剂的空间限制是一种有效的策略，可在一锅反应中进行顺序或串联的化学转化。这些方法可用于在催化剂与溶剂，不同催化剂或试剂之间不相容的条件下催化大量反应。适当的场地隔离或支撑结构设计将在原子经济，纯化和成本上带来显着优势；催化剂及其受限的微环境之间界面的发展对于实现下一代纳米反应器至关重要。聚合物支架可以创建量身定制的微环境，从而导致催化剂分隔。通过优化多种变量，例如纳米反应器的大小，溶解度，功能和形态，可以调节催化剂的活性和选择性。在这篇专题文章中，介绍了用于催化剂位点隔离的聚合物载体的设计原理和早期策略，并讨论了用于非正交级联催化的多隔室聚合物纳米反应器的当前策略。结论中概述了这个新兴领域的未来设计趋势。