A radical cyclization cascade of 2-alkynylbenzonitriles with sodium arylsulfinates,Organic & Biomolecular Chemistry

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A radical cyclization cascade of 2-alkynylbenzonitriles with sodium arylsulfinates
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-10-15 , DOI: 10.1039/c8ob02288g
Bang Zhou _{1,

2,

3,

4,

5} , Wenqi Chen _{1,

2,

3,

4,

5} , Yuzhong Yang _{1,

2,

3,

4,

5} , Yuan Yang _{1,

2,

3,

4,

5} , Guobo Deng _{1,

2,

3,

4,

5} , Yun Liang _{1,

2,

3,

4,

5}

Affiliation

A convenient radical cyclization cascade procedure for the construction of sulfonated indenones from 2-alkynylbenzonitriles and sodium arylsulfinates has been explored under mild reaction conditions. The present methodology offers a low-cost and operationally straightforward approach to synthesizing various sulfonated indenones in moderate to good yields by simple use of cheap sodium persulfate as an oxidant and environmentally benign water as a co-solvent.

中文翻译：

2-炔基苄腈与芳基亚磺酸钠的自由基环化级联反应

在温和的反应条件下，研究了一种方便的自由基环化级联方法，用于由2-炔基苄腈和芳基亚磺酸钠构建磺化茚满。本方法通过简单地使用廉价的过硫酸钠作为氧化剂和对环境无害的水作为助溶剂，提供了一种以中等到良好的产率合成各种磺化茚满的低成本且操作简便的方法。

更新日期：2018-11-02

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