Synthesis of porous Pd nanoparticles by therapeutic chaga extract for highly efficient tri-modal cancer treatment†,Nanoscale

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Synthesis of porous Pd nanoparticles by therapeutic chaga extract for highly efficient tri-modal cancer treatment†
Nanoscale ( IF 5.8 ) Pub Date : 2018-10-13 00:00:00 , DOI: 10.1039/c8nr07172a
Yeong-Gyu Gil _{1,

2,

3,

4} , Seounghun Kang _{1,

4,

5,

6,

7} , Ari Chae _{4,

8,

9,

10,

11} , Young-Kwan Kim _{4,

8,

9,

10,

11} , Dal-Hee Min _{1,

4,

5,

6,

7} , Hongje Jang _{1,

2,

3,

4}

Affiliation

Porous palladium nanoparticles were designed and synthesized to maximize the pharmacological activity of the chaga mushroom (Inonotus obliquus) extract, which has anticancer and antibacterial activities. In the present study, we synthesized anisotropic porous Pd nanostructures with ultraviolet-visible-near infrared whole wavelength region absorption using chaga extract concentration-dependent reductant-mediated synthesis. The porous Pd nanoparticles exhibited a surface chaga extract-derived anticancer effect, controlled delivery of doxorubicin through electrostatic interaction, and a photothermal conversion effect under 808 nm laser irradiation. The combined application of the three cancer treatment approaches clearly demonstrated the feasibility of synergistic tri-modal therapy. The present platform using Pd, which is a key constituent element of nanocatalysts but is not commonly used in biological applications, suggests numerous applications utilizing Pd nanostructures, as well as the potential development of new cancer therapies.

中文翻译：

用治疗性Chaga提取物合成多孔Pd纳米颗粒，可高效治疗三峰癌症†

设计并合成了多孔钯纳米粒子，以最大化查加蘑菇（Inonotus obliquus）的药理活性。）提取物，具有抗癌和抗菌活性。在本研究中，我们使用chaga提取物浓度依赖性还原剂介导的合成方法，合成了具有紫外-可见-近红外全波长区域吸收的各向异性多孔Pd纳米结构。多孔Pd纳米颗粒具有表面Chaga提取物的抗癌作用，通过静电相互作用控制阿霉素的递送以及在808 nm激光照射下的光热转化作用。三种癌症治疗方法的联合应用清楚地证明了协同三峰疗法的可行性。目前使用的Pd平台是纳米催化剂的关键组成元素，但在生物学应用中并不常用，它提出了许多利用Pd纳米结构的应用，

更新日期：2018-10-13

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