Abstract Dual cancer therapy is an attractive strategy that can generate synergistic effects and also reduce drug-related side effects. Here, we developed multifunctional nanocomplexes capable of remote on-demand production of hyperthermia and free radicals in response to near infrared (NIR) light irradiation To this end, thermal initiator and gold nanorods were embedded in nano-sized temperature-responsive poly(lactic acid-co-glycolic acid). In vitro studies demonstrated controllable heat and radical production from the nanocomplexes with NIR and effective eradication of CT26 colon cancer cells with our nanocomplexes. Hence, our smart nanomaterial will potentially contribute precise and effective dual cancer treatment.

中文翻译：

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使用热引发剂和金纳米棒嵌入的 PLGA 纳米复合物按需产生热量和自由基用于双重癌症治疗

摘要 癌症双重治疗是一种有吸引力的策略，可以产生协同效应并减少药物相关的副作用。在这里，我们开发了多功能纳米复合物，能够响应近红外 (NIR) 光照射远程按需生产热疗和自由基为此，热引发剂和金纳米棒嵌入纳米级温度响应聚乳酸-共-乙醇酸）。体外研究表明，纳米复合物可以通过 NIR 控制热量和自由基的产生，并且我们的纳米复合物可以有效根除 CT26 结肠癌细胞。因此，我们的智能纳米材料可能有助于精确有效的双重癌症治疗。