The process of postcondensation for the functionalization of mesoporous silica is based on the cooperation between the end-on growth of arrays of silica nanochannels and the steric hindrance of the functional silanes (R-silanes). To obtain particles with differently functionalized surfaces (thiol and amino groups), the delayed addition of another R-silane was introduced. This tandem postcondensation approach allows for three selective functionalization strategies, depending on the mobility and the steric hindrance of the R-silanes. Following these one-pot synthesis strategies, functional groups can be placed independently on the pore entrances and on the internal surface of the mesoporous silica particles. Confocal laser scanning microscopy was used to image the functional group distribution after selective coupling with a fluorescent dye. Nitrogen sorption measurements were conducted to confirm the well-defined mesoporosity of the functionalized products.

中文翻译：

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通过一锅法合成在介孔二氧化硅颗粒中定位多个官能团的策略

中孔二氧化硅功能化的后缩合过程基于二氧化硅纳米通道阵列末端生长与功能性硅烷（R-硅烷）的位阻之间的协作。为了获得具有不同官能化表面（硫醇和氨基）的颗粒，引入了另一种R-硅烷的延迟添加。根据R-硅烷的迁移率和位阻，这种串联后缩合方法允许三种选择性官能化策略。按照这些一锅合成策略，可以将官能团独立地放置在介孔二氧化硅颗粒的孔入口和内表面上。与荧光染料选择性偶联后，使用共聚焦激光扫描显微镜对官能团分布进行成像。