The combination of cell culture models with microscale technology has fostered emergence of in vitro cell‐based microphysiological models, also known as organ‐on‐a‐chip systems. Body‐on‐a‐chip (BOC) systems, which are multiorgan systems on a chip to mimic physiological relations, enable recapitulation of organ–organ interactions and potentially whole‐body response to drugs, as well as serve as models of diseases. Chemical reaction engineering principles can be applied to understanding complex reactions inside the cell or human body, which can be treated as a multireactor system. These systems use physiologically based pharmacokinetic models to guide the development of microscale systems of the body where organs or tissues are represented by living cells or tissues, and integrated into BOC systems. Here, we provide a brief overview on the concept of chemical reaction engineering and how its principles can be applied to understanding and predicting the behavior of BOC systems. © 2018 American Institute of Chemical Engineers AIChE J, 64: 4351–4360, 2018

中文翻译：

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化学反应工程原理在“单芯片”系统中的应用

细胞培养模型与微尺度技术的结合促进了体外出现基于细胞的微生理模型，也称为芯片上器官系统。芯片上的身体（BOC）系统是芯片上的多器官系统，用于模仿生理关系，可以概括器官与器官之间的相互作用以及潜在的全身对药物的反应，还可以作为疾病的模型。化学反应工程原理可用于理解细胞或人体内部的复杂反应，可将其视为多反应器系统。这些系统使用基于生理学的药代动力学模型来指导人体微观系统的发展，在该系统中，器官或组织以活细胞或组织为代表，并整合到BOC系统中。这里，我们简要概述了化学反应工程的概念以及如何将其原理应用于理解和预测BOC系统的行为。©2018美国化学工程师学会AIChE J，64：4351–4360，2018年