Overcoming the multidrug-resistant (MDR) bacterial infection is a challenge and urgently needed in wound healing. Few wound dressings possess the capacity to treat MDR bacterial infections and enhance wound healing. Herein, we develop an elastomeric, photoluminescent, and antibacterial hybrid polypeptide-based nanofibrous matrix as a multifunctional platform to inhibit the MDR bacteria and enhance wound healing. The hybrid nanofibrous matrix was composed of poly(citrate)-ε-poly lysine (PCE) and poly caprolactone (PCL). The PCL–PCE hybrid nanofibrous matrix showed a biomimetic elastomeric behavior, robust antibacterial activity including killing MDR bacteria capacity, and excellent biocompatibility. PCL–PCE nanofibrous system can efficiently prevent the MDR bacteria-derived wound infection and significantly enhance the complete skin-thickness wound healing and skin regeneration in a mouse model. PCL–PCE hybrid nanofibrous matrix might become a competitive multifunctional dressing for bacteria-infected wound healing and skin regeneration.

中文翻译：

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基于仿生弹性体多肽的纳米纤维基质，可克服耐多药细菌并增强全层伤口愈合/皮肤再生

克服多药耐药性（MDR）细菌感染是一项挑战，在伤口愈合中迫切需要。很少有伤口敷料具有治疗MDR细菌感染和增强伤口愈合的能力。在本文中，我们开发了一种弹性体，光致发光和抗菌的杂合多肽基纳米纤维基质，作为抑制MDR细菌和增强伤口愈合的多功能平台。杂化纳米纤维基质由聚（柠檬酸盐）-ε-聚赖氨酸（PCE）和聚己内酯（PCL）组成。PCL–PCE杂化纳米纤维基质表现出仿生的弹性体行为，强大的抗菌活性（包括杀死MDR细菌的能力）和出色的生物相容性。PCL–PCE纳米纤维系统可以有效预防MDR细菌引起的伤口感染，并显着增强小鼠模型中完整的皮肤厚度伤口愈合和皮肤再生。PCL–PCE杂合纳米纤维基质可能会成为细菌感染的伤口愈合和皮肤再生的竞争性多功能敷料。