Fabrication of biocleavable shell cross-linked hybrid micelles for controlled drug release using a reducible silica monomer†,Chemical Communications

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Fabrication of biocleavable shell cross-linked hybrid micelles for controlled drug release using a reducible silica monomer†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-10-12 00:00:00 , DOI: 10.1039/c8cc06685j
Xianshuo Zhang _{1,

2,

3} , Xiaolong Zhang _{1,

2,

3} , Lu Sun _{1,

2,

3} , Fangjun Liu _{1,

2,

3} , Mingqi Wang _{1,

2,

3} , Jinlei Peng _{1,

2,

3} , Yunfei Wang _{1,

2,

3} , Liwei Ma _{1,

2,

3} , Baoyan Wang _{1,

2,

3} , Hua Wei _{1,

2,

3}

Affiliation

We report in this communication the first preparation of triblock copolymer-based biocleavable shell cross-linked (SCL) hybrid micelles using a reducible silica monomer that integrates a polymerizable methacrylate structure and in situ cross-linkers of silica precursors via a disulfide bond. The monomer developed herein offers a highly straightforward and robust strategy toward bioreducible silica-based hybrid nanoparticles for controlled drug release.

中文翻译：

使用可还原的二氧化硅单体制备可生物裂解的壳交联杂化胶束以控制药物释放†

我们在本次交流中报告了使用可还原的二氧化硅单体制备的基于三嵌段共聚物的可生物裂解的壳交联（SCL）杂化胶束的首次制备，该单体整合了可聚合的甲基丙烯酸酯结构和二氧化硅前体的原位交联剂通过二硫键。本文开发的单体为生物可还原的基于二氧化硅的杂化纳米颗粒提供了一种非常直接且可靠的策略，以控制药物的释放。

更新日期：2018-10-12

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