Wheat is one of the most important agricultural crops worldwide. Recently, anthocyanin-rich wheat genotypes were introduced to the market as a food with added value. In the experiment described here, two different genotypes with blue grain were studied (UC66049 and Skorpion). The aim of the investigation was to determine whether a 72-day-long intake of anthocyanin-rich wheat can influence the drug-metabolizing microsomal cytochromes P450 (using standard drug substrates of rat/human liver microsomal cytochromes P450) and antioxidant status, which indicated the ability of the rats' liver to metabolize drugs or xenobiotics. Consumption of an anthocyanin-rich diet moderately increased the activity and mRNA expression of the studied CYPs by 20–55% relative to the control (with the exception of CYP2B1/2). The health status of rats was good; the weight gain was lower in the group with anthocyanin-rich UC66049 grain compared to the other two groups (control and Skorpion-fed one). The antioxidant power of plasma was mildly but significantly higher in the test groups, other antioxidant parameters remained unaffected, except for an increased level of total SH groups. Based on our observations, there will most likely be no significant influence of the consumption of anthocyanin-rich wheat on the metabolism of xenobiotics and drugs.

小麦是世界上最重要的农作物之一。最近，富含花青素的小麦基因型作为具有附加值的食品被推向市场。在此处描述的实验中，研究了两种具有蓝色颗粒的不同基因型（UC66049和Skorpion）。研究的目的是确定72天摄入富含花青素的小麦是否会影响药物代谢微粒体细胞色素P450（使用大鼠/人肝脏微粒体细胞色素P450的标准药物底物）和抗氧化剂状态，这表明大鼠肝脏代谢药物或异种生物的能力。食用富含花青素的饮食相对于对照组（CYP2B1 / 2除外），使所研究的CYP的活性和mRNA表达适度增加了20-55％。大鼠的健康状况良好；与其他两组（对照组和Skorpion喂养的一组）相比，富含花青素的UC66049谷物的组的增重较低。在测试组中，血浆的抗氧化能力是温和的，但明显更高，其他抗氧化参数除了总含量增加外，其余均不受影响SH组。根据我们的观察，富含花青素的小麦的摄入对异源生物和药物代谢的影响极有可能不会受到重大影响。