Notch is a transmembrane receptor that mediates intercellular signaling through a conserved signaling cascade in all animal species. Transcriptional and posttranscriptional regulation of Notch receptor are important for maintaining Notch signaling activity. Here, we show that depletion of Drosophila Sin3A leads to loss of the adult wing margin and downregulation of Notch target gene expression in the developing wing disc. Sin3A regulates the Notch pathway downstream of Delta and upstream of Notch activation. The role of Sin3A in the Notch pathway is partly mediated by its ability to modulate Notch receptor transcription. Furthermore, the transcriptional activation of Notch receptor is autoregulated by Notch itself. We also provide evidence that Sin3A is required for Notch activation mediated Notch transcription. Together, our data demonstrate that Sin3A activates Notch signaling by promoting Notch transcription and reveal a previously unknown autoregulatory mechanism for Notch signaling activation during Drosophila wing development.

中文翻译：

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Sin3A在调节果蝇翅膀发育过程中的Notch信号中起积极作用。

Notch是一种跨膜受体，它通过所有动物物种中保守的信号传导级联介导细胞间信号传导。Notch受体的转录和转录后调控对于维持Notch信号传导活性很重要。在这里，我们表明果蝇Sin3A的消耗导致成年机翼边缘的损失和发育中翼盘中Notch目标基因表达的下调。Sin3A调节Delta下游和Notch激活上游的Notch途径。Sin3A在Notch途径中的作用部分由其调节Notch受体转录的能力介导。此外，Notch受体的转录激活由Notch自身自动调节。我们还提供证据表明，Notch激活介导的Notch转录需要Sin3A。一起，