Injectable and Spatially Patterned Microporous Annealed Particle (MAP) Hydrogels for Tissue Repair Applications,Advanced Science

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Injectable and Spatially Patterned Microporous Annealed Particle (MAP) Hydrogels for Tissue Repair Applications
Advanced Science ( IF 14.3 ) Pub Date : 2018-10-11 , DOI: 10.1002/advs.201801046
Nicole J Darling ₁ , Elias Sideris ₁ , Naomi Hamada ₁ , S Thomas Carmichael ₂ , Tatiana Segura ₁

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Spatially patterned hydrogels are becoming increasingly popular in the field of regenerative medicine and tissue repair because of their ability to guide cell infiltration and migration. However, postfabrication technologies are usually required to spatially pattern a hydrogel, making these hydrogels difficult to translate into the clinic. Here, an injectable spatially patterned hydrogel is reported using hyaluronic acid (HA)‐based particle hydrogels. These particle hydrogels are sequentially loaded into a syringe to form a pattern and, once injected, they maintain the pattern. The applicability of this hydrogel in a wound healing skin model, a subcutaneous implant model, as well as a stroke brain model is examined and distinct patterning in all models tested is shown. This injectable and spatially patterned hydrogel can be used to create physical or biochemical gradients. Further, this design can better match the scaffold properties within the physical location of the tissue (e.g., wound border vs wound center). This allows for better design features within the material that promote repair and regeneration.

中文翻译：

用于组织修复应用的可注射和空间图案化微孔退火颗粒 (MAP) 水凝胶

空间图案水凝胶由于其引导细胞浸润和迁移的能力而在再生医学和组织修复领域变得越来越受欢迎。然而，通常需要后制造技术来对水凝胶进行空间图案化，使得这些水凝胶难以转化为临床。在此，报道了一种使用基于透明质酸（HA）的颗粒水凝胶的可注射空间图案水凝胶。这些颗粒水凝胶被依次装入注射器中以形成图案，并且一旦注射，它们就会保持该图案。检查了这种水凝胶在伤口愈合皮肤模型、皮下植入模型以及中风脑模型中的适用性，并显示了所有测试模型中的独特图案。这种可注射的空间图案水凝胶可用于创建物理或生化梯度。此外，这种设计可以更好地匹配组织物理位置内的支架特性（例如，伤口边缘与伤口中心）。这使得材料具有更好的设计特征，促进修复和再生。

更新日期：2018-10-11

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