Recent work published by Rovis, Schoenebeck, and co-workers in Nature Chemistry describes a synergistic CO₂ mediation and photocatalysis strategy for challenging α-alkylation of primary aliphatic amines by using quinuclidine as a hydrogen atom transfer (HAT) catalyst for γ-lactam synthesis. Electrostatic attraction between the in-situ-generated carbamate and quinuclidinium radical cation is critical for the selectivity.

中文翻译：

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协同CO ₂介导和光催化伯脂肪胺的α-烷基化

Rovis，Schoenebeck及其同事在Nature Chemistry上发表的最新工作描述了一种协同的CO ₂介导和光催化策略，该方法通过使用奎尼丁作为γ-内酰胺合成的氢原子转移（HAT）催化剂来挑战伯脂肪胺的α-烷基化。的之间的静电吸引在-原位-生成氨基甲酸酯和奎宁环鎓阳离子自由基是用于选择性的关键。