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Straightforward Synthesis of Triester-Substituted Pyrrolizidines by a Three-Component Reaction of β,γ-Unsaturated α-Keto Esters, Proline, and Maleates
Synlett ( IF 1.7 ) Pub Date : 2018-10-11 , DOI: 10.1055/s-0037-1611061 Lian-Mei Chen 1 , Tai-Ran Kang 1, 2 , Zhi-Hui Liu 2 , Xu-Feng Nie 2 , Xiao-Qiang Guo 1
Synlett ( IF 1.7 ) Pub Date : 2018-10-11 , DOI: 10.1055/s-0037-1611061 Lian-Mei Chen 1 , Tai-Ran Kang 1, 2 , Zhi-Hui Liu 2 , Xu-Feng Nie 2 , Xiao-Qiang Guo 1
Affiliation
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A three-component reaction of β,γ-unsaturated α-keto esters, proline, and dialkyl maleates has been developed. This reaction provides pyrrolizidine derivatives containing three ester groups and a styrenyl group, as well as a quaternary center, in moderate to good yields and with good to excellent diastereoselectivities.
中文翻译：
通过 β,γ-不饱和 α-酮酯、脯氨酸和马来酸酯的三组分反应直接合成三酯取代的吡咯里西啶
已开发出 β,γ-不饱和 α-酮酯、脯氨酸和马来酸二烷基酯的三组分反应。该反应以中等至良好的产率和良好至极好的非对映选择性提供含有三个酯基和一个苯乙烯基以及一个季铵的吡咯里西啶衍生物。
更新日期：2018-10-11
中文翻译：
通过 β,γ-不饱和 α-酮酯、脯氨酸和马来酸酯的三组分反应直接合成三酯取代的吡咯里西啶
已开发出 β,γ-不饱和 α-酮酯、脯氨酸和马来酸二烷基酯的三组分反应。该反应以中等至良好的产率和良好至极好的非对映选择性提供含有三个酯基和一个苯乙烯基以及一个季铵的吡咯里西啶衍生物。
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