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Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy
ACS Nano ( IF 15.8 ) Pub Date : 2018-10-11 00:00:00 , DOI: 10.1021/acsnano.8b05937 Nuernisha Alifu 1 , Abudureheman Zebibula 1, 2 , Ji Qi 3 , Hequn Zhang 1 , Chaowei Sun 1 , Xiaoming Yu 2 , Dingwei Xue 2 , Jacky W Y Lam 3 , Gonghui Li 2 , Jun Qian 1, 2 , Ben Zhong Tang 3, 4
ACS Nano ( IF 15.8 ) Pub Date : 2018-10-11 00:00:00 , DOI: 10.1021/acsnano.8b05937 Nuernisha Alifu 1 , Abudureheman Zebibula 1, 2 , Ji Qi 3 , Hequn Zhang 1 , Chaowei Sun 1 , Xiaoming Yu 2 , Dingwei Xue 2 , Jacky W Y Lam 3 , Gonghui Li 2 , Jun Qian 1, 2 , Ben Zhong Tang 3, 4
Affiliation
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Second near-infrared (NIR-II, 1000–1700 nm) fluorescence bioimaging has attracted tremendous scientific interest and already been used in many biomedical studies. However, reports on organic NIR-II fluorescent probes for in vivo photoinduced imaging and simultaneous therapy, as well as the long-term tracing of specific biological objects, are still very rare. Herein we designed a single-molecular and NIR-II-emissive theranostic system by encapsulating a kind of aggregation-induced emission luminogen (AIEgen, named BPN-BBTD) with amphiphilic polymer. The ultra-stable BPN-BBTD nanoparticles were employed for the NIR-II fluorescence imaging and photothermal therapy of bladder tumors in vivo. The 785 nm excitation triggered photothermal therapy could completely eradicate the subcutaneous tumor and inhibit the growth of orthotopic tumors. Furthermore, BPN-BBTD nanoparticles were capable of monitoring subcutaneous and orthotopic tumors for a long time (32 days). Single-molecular and NIR-II-emitted aggregation-induced emission nanoparticles hold potential for the diagnosis, precise treatment, and metastasis monitoring of tumors in the future.
中文翻译：
单分子近红外-II 治疗系统：用于长期追踪和高效光热治疗的超稳定聚集诱导发射纳米粒子
第二近红外（NIR-II，1000-1700 nm）荧光生物成像引起了巨大的科学兴趣，并已用于许多生物医学研究。然而，关于用于体内光诱导成像和同步治疗的有机 NIR-II 荧光探针以及对特定生物对象的长期追踪的报道仍然非常罕见。在此，我们通过用两亲聚合物封装一种聚集诱导发射发光体（AIEgen，命名为 BPN-BBTD）设计了一种单分子和 NIR-II 发射治疗诊断系统。超稳定的 BPN-BBTD 纳米颗粒用于体内膀胱肿瘤的 NIR-II 荧光成像和光热治疗. 785 nm激发触发的光热疗法可以彻底根除皮下肿瘤并抑制原位肿瘤的生长。此外，BPN-BBTD 纳米颗粒能够长时间（32 天）监测皮下和原位肿瘤。单分子和 NIR-II 发射的聚集诱导发射纳米粒子在未来对肿瘤的诊断、精确治疗和转移监测具有潜力。
更新日期：2018-10-11
中文翻译：
单分子近红外-II 治疗系统：用于长期追踪和高效光热治疗的超稳定聚集诱导发射纳米粒子
第二近红外（NIR-II，1000-1700 nm）荧光生物成像引起了巨大的科学兴趣，并已用于许多生物医学研究。然而，关于用于体内光诱导成像和同步治疗的有机 NIR-II 荧光探针以及对特定生物对象的长期追踪的报道仍然非常罕见。在此，我们通过用两亲聚合物封装一种聚集诱导发射发光体（AIEgen，命名为 BPN-BBTD）设计了一种单分子和 NIR-II 发射治疗诊断系统。超稳定的 BPN-BBTD 纳米颗粒用于体内膀胱肿瘤的 NIR-II 荧光成像和光热治疗. 785 nm激发触发的光热疗法可以彻底根除皮下肿瘤并抑制原位肿瘤的生长。此外，BPN-BBTD 纳米颗粒能够长时间（32 天）监测皮下和原位肿瘤。单分子和 NIR-II 发射的聚集诱导发射纳米粒子在未来对肿瘤的诊断、精确治疗和转移监测具有潜力。
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