Bovine leukemia virus (BLV) is a widespread infection that can affect innate and adaptive immunity; however, little information exists on how BLV infection affects foot-and-mouth disease virus (FMDV) vaccination programs. Vaccination for FMDV is compulsory in many regions of the world, and vaccine efficacy is monitored by measuring total antibodies against this virus. In a previous study, we observed that BLV-infected heifers produced a lower amount of antibodies in response to FMDV at first vaccination. In this follow-up study, we show that BLV status does not interfere with the total level and avidity of anti-FMDV–specific antibodies induced after repetitive routine vaccination in adult cattle. This is relevant information for the proficiency of vaccine-based FMDV control programs in BLV-endemic regions.

牛白血病病毒（BLV）是一种广泛的感染，可以影响先天和适应性免疫。但是，关于BLV感染如何影响口蹄疫病毒（FMDV）疫苗接种计划的信息很少。FMDV的疫苗接种在世界许多地区都是强制性的，并且可以通过测量针对该病毒的总抗体来监测疫苗的功效。在先前的研究中，我们观察到BLV感染的小母牛在初次接种疫苗时对FMDV的反应产生的抗体量较低。在这项后续研究中，我们显示成年牛重复常规疫苗接种后，BLV状态不会干扰抗FMDV特异性抗体的总水平和亲和力。这是有关BLV流行地区基于疫苗的FMDV控制程序熟练程度的相关信息。