Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Pathogen elimination by probiotic Bacillus via signalling interference
Nature ( IF 50.5 ) Pub Date : 2018-10-01 , DOI: 10.1038/s41586-018-0616-y Pipat Piewngam 1, 2 , Yue Zheng 1 , Thuan H Nguyen 1 , Seth W Dickey 1 , Hwang-Soo Joo 1, 3 , Amer E Villaruz 1 , Kyle A Glose 1 , Emilie L Fisher 1 , Rachelle L Hunt 1 , Barry Li 1 , Janice Chiou 1 , Sujiraphong Pharkjaksu 2 , Sunisa Khongthong 4 , Gordon Y C Cheung 1 , Pattarachai Kiratisin 2 , Michael Otto 1
Nature ( IF 50.5 ) Pub Date : 2018-10-01 , DOI: 10.1038/s41586-018-0616-y Pipat Piewngam 1, 2 , Yue Zheng 1 , Thuan H Nguyen 1 , Seth W Dickey 1 , Hwang-Soo Joo 1, 3 , Amer E Villaruz 1 , Kyle A Glose 1 , Emilie L Fisher 1 , Rachelle L Hunt 1 , Barry Li 1 , Janice Chiou 1 , Sujiraphong Pharkjaksu 2 , Sunisa Khongthong 4 , Gordon Y C Cheung 1 , Pattarachai Kiratisin 2 , Michael Otto 1
Affiliation
|
Probiotic nutrition is frequently claimed to improve human health. In particular, live probiotic bacteria obtained with food are thought to reduce intestinal colonization by pathogens, and thus to reduce susceptibility to infection. However, the mechanisms that underlie these effects remain poorly understood. Here we report that the consumption of probiotic Bacillus bacteria comprehensively abolished colonization by the dangerous pathogen Staphylococcus aureus in a rural Thai population. We show that a widespread class of Bacillus lipopeptides, the fengycins, eliminates S. aureus by inhibiting S. aureus quorum sensing—a process through which bacteria respond to their population density by altering gene regulation. Our study presents a detailed molecular mechanism that underlines the importance of probiotic nutrition in reducing infectious disease. We also provide evidence that supports the biological significance of probiotic bacterial interference in humans, and show that such interference can be achieved by blocking a pathogen’s signalling system. Furthermore, our findings suggest a probiotic-based method for S. aureus decolonization and new ways to fight S. aureus infections.Lipopeptides secreted by Bacillus bacteria block quorum sensing by Staphylococcus aureus and thereby inhibit the growth of this opportunistic pathogen in the gut, suggesting why people in rural Thailand who are colonized by Bacillus are not also colonized by S. aureus.
中文翻译：
益生菌芽孢杆菌通过信号干扰消除病原体
益生菌营养经常被声称可以改善人类健康。特别是，通过食物获得的活益生菌被认为可以减少病原体在肠道的定植，从而降低感染的易感性。然而，这些影响背后的机制仍然知之甚少。在这里，我们报告说，食用益生芽孢杆菌彻底消除了泰国农村人口中危险病原体金黄色葡萄球菌的定植。我们发现，一类广泛存在的芽孢杆菌脂肽（风霉素）通过抑制金黄色葡萄球菌群体感应来消除金黄色葡萄球菌，群体感应是细菌通过改变基因调控来响应其群体密度的过程。我们的研究提出了详细的分子机制，强调了益生菌营养在减少传染病方面的重要性。我们还提供证据支持益生菌干扰对人类的生物学意义，并表明这种干扰可以通过阻断病原体的信号系统来实现。此外，我们的研究结果提出了一种基于益生菌的金黄色葡萄球菌去定植方法和对抗金黄色葡萄球菌感染的新方法。芽孢杆菌分泌的脂肽阻断金黄色葡萄球菌的群体感应，从而抑制这种机会性病原体在肠道中的生长，这表明为什么泰国农村地区被芽孢杆菌定殖的人们不会同时被金黄色葡萄球菌定殖。
更新日期：2018-10-01
中文翻译：
益生菌芽孢杆菌通过信号干扰消除病原体
益生菌营养经常被声称可以改善人类健康。特别是，通过食物获得的活益生菌被认为可以减少病原体在肠道的定植，从而降低感染的易感性。然而，这些影响背后的机制仍然知之甚少。在这里，我们报告说，食用益生芽孢杆菌彻底消除了泰国农村人口中危险病原体金黄色葡萄球菌的定植。我们发现，一类广泛存在的芽孢杆菌脂肽（风霉素）通过抑制金黄色葡萄球菌群体感应来消除金黄色葡萄球菌，群体感应是细菌通过改变基因调控来响应其群体密度的过程。我们的研究提出了详细的分子机制，强调了益生菌营养在减少传染病方面的重要性。我们还提供证据支持益生菌干扰对人类的生物学意义，并表明这种干扰可以通过阻断病原体的信号系统来实现。此外，我们的研究结果提出了一种基于益生菌的金黄色葡萄球菌去定植方法和对抗金黄色葡萄球菌感染的新方法。芽孢杆菌分泌的脂肽阻断金黄色葡萄球菌的群体感应，从而抑制这种机会性病原体在肠道中的生长，这表明为什么泰国农村地区被芽孢杆菌定殖的人们不会同时被金黄色葡萄球菌定殖。
京公网安备 11010802027423号