Rational design of a super-contrast NIR-II fluorophore affords high-performance NIR-II molecular imaging guided microsurgery†,Chemical Science

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Rational design of a super-contrast NIR-II fluorophore affords high-performance NIR-II molecular imaging guided microsurgery†
Chemical Science ( IF 7.6 ) Pub Date : 2018-10-10 00:00:00 , DOI: 10.1039/c8sc03751e
Rui Tian ₁ , Huilong Ma ₂ , Qinglai Yang _{2,

3} , Hao Wan ₄ , Shoujun Zhu ₁ , Swati Chandra ₁ , Haitao Sun ₅ , Dale O Kiesewetter ₁ , Gang Niu ₁ , Yongye Liang ₂ , Xiaoyuan Chen ₁

Affiliation

In vivo molecular imaging in the “transparent” near-infrared II (NIR-II) window has demonstrated impressive benefits in reaching millimeter penetration depths with high specificity and imaging quality. Previous NIR-II molecular imaging generally relied on high hepatic uptake fluorophores with an unclear mechanism and antibody-derived conjugates, suffering from inevitable nonspecific retention in the main organs/skin with a relatively low signal-to-background ratio. It is still challenging to synthesize a NIR-II fluorophore with both high quantum yield and minimal liver-retention feature. Herein, we identified the structural design and excretion mechanism of novel NIR-II fluorophores for NIR-II molecular imaging with an extremely clean background. With the optimized renally excreted fluorophore–peptide conjugates, superior NIR-II targeting imaging was accompanied by the improved signal-to-background ratio during tumor detection with reducing off-target tissue exposure. An unprecedented NIR-II imaging-guided microsurgery was achieved using such an imaging platform, which provides us with a great preclinical example to accelerate the potential clinical translation of NIR-II imaging.

中文翻译：

超对比度 NIR-II 荧光团的合理设计可提供高性能 NIR-II 分子成像引导显微手术†

“透明”近红外 II (NIR-II) 窗口中的体内分子成像在达到毫米级穿透深度、高特异性和成像质量方面表现出了令人印象深刻的优势。以前的 NIR-II 分子成像通常依赖于机制尚不清楚的高肝脏摄取荧光团和抗体衍生的缀合物，不可避免地会在主要器官/皮肤中出现非特异性滞留，信号背景比相对较低。合成具有高量子产率和最小肝脏保留特征的 NIR-II 荧光团仍然具有挑战性。在此，我们确定了新型 NIR-II 荧光团的结构设计和排泄机制，用于具有极其干净的背景的 NIR-II 分子成像。通过优化的肾排泄荧光团-肽缀合物，卓越的 NIR-II 靶向成像伴随着肿瘤检测过程中信号背景比的改善，并减少了脱靶组织暴露。使用这样的成像平台实现了前所未有的NIR-II成像引导显微手术，这为我们加速NIR-II成像潜在的临床转化提供了一个很好的临床前例子。

更新日期：2018-10-10

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