A variety of enantioenriched 3‐N‐substituted spirooxindole‐dihydroquinazolinones were synthesized by cyclization reactions involving 2‐amino‐N‐substituted benzamides and isatins catalyzed by SPINOL‐CPA catalyst in a highly enantioselective manner with excellent ee values (up to 99%) and good yields (up to 99%). So far, this is the first example to directly access this type of chiral pharmaceutically privileged 3‐N‐substituted dihydroquinazolinone derivatives with a broad substrate scope.

中文翻译：

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N-取代的邻氨基苯甲酰胺与Isatins的环化反应合成螺氧基吲哚-二氢喹唑啉酮

通过SPINOL-CPA催化剂催化的2-氨基-N-取代的苯甲酰胺和靛红的环化反应，以高对映体选择性的方式，以优异的ee值（高达99％）和（-）的反应，合成了多种对映体富集的3-N-取代的螺氧基吲哚-二氢喹唑啉酮。良率（高达99％）。到目前为止，这是第一个直接获得具有广泛底物范围的手性药学特权的3-N-取代的二氢喹唑啉酮衍生物的实例。