Sandwich‐Like Fibers/Sponge Composite Combining Chemotherapy and Hemostasis for Efficient Postoperative Prevention of Tumor Recurrence and Metastasis,Advanced Materials

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Sandwich‐Like Fibers/Sponge Composite Combining Chemotherapy and Hemostasis for Efficient Postoperative Prevention of Tumor Recurrence and Metastasis
Advanced Materials ( IF 27.4 ) Pub Date : 2018-10-10 , DOI: 10.1002/adma.201803217
Zhiyun Zhang ₁ , Gaizhen Kuang _{1,

2} , Shan Zong ₃ , Shi Liu ₁ , Haihua Xiao ₄ , Xuesi Chen ₅ , Dongfang Zhou ₁ , Yubin Huang ₁

Affiliation

Intraoperative bleeding is an essential factor leading to the earliest recurrence and tumor metastasis frequently seen after resection of solid tumors. Local drug delivery implants show the unique advantages on postoperative cancer therapy. Herein, a sandwich‐like cisplatin‐loaded fibers/sponge composite (CFSC) combining chemotherapy and hemostasis is constructed. The obtained implantable CFSC is able to simultaneously stop bleeding and absorb disseminated tumor cells after tumor resection. More importantly, sustained released cisplatin can kill local residual tumor cells as well as those concentrated in the CFSC, which significantly inhibits local tumor recurrence and distant tumor metastasis on the subcutaneous postoperative recurrence model and metastasis models. This dual functional implant strategy with low toxicity to healthy organs may inspire new aspects for efficient postoperative cancer therapy.

中文翻译：

三明治式纤维/海绵复合材料结合化学疗法和止血药，可有效预防术后肿瘤的复发和转移

术中出血是导致实体瘤切除术后常见的最早复发和肿瘤转移的重要因素。局部药物递送植入物在术后癌症治疗中显示出独特的优势。本文构建了一种将化学疗法和止血相结合的类似三明治的顺铂纤维/海绵复合材料（CFSC）。所获得的植入式CFSC能够在肿瘤切除后同时止血并吸收扩散的肿瘤细胞。更重要的是，持续释放的顺铂可以杀死局部残留的肿瘤细胞以及集中在CFSC中的细胞，从而在皮下术后复发模型和转移模型上显着抑制局部肿瘤的复发和远处的肿瘤转移。

更新日期：2018-10-10

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