Abstract

Use of cyanoacetohydrazides as precursors in reactions leading to construction of heterocycles is reviewed. In addition to some common heterocyclic compounds, synthesis of other uncommon heterocycles such as thiadiazole, oxadiazole, fused heterocycles, and some seven- and eight-membered heterocycles such as benzodiazepine, oxazepine, and benzoxocine starting with cyanoacetohydrazides and their derivatives is also reported. The main aim of this review is to show the application of cyanoacetohydrazides in heterocyclic synthesis via different types of reaction, including cyclocondensation and cyclization. The results are arranged in terms of the type of heterocycle formed, from five-, six-, seven-, to eight-membered and fused rings. This review aims to cover literature up to 2018, showing the distribution of publications involving use of cyanoacetohydrazides for preparation of heterocycles.

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摘要

综述了氰基乙酰肼作为前体在导致杂环结构构建的反应中的应用。除某些常见的杂环化合物外，还报道了以氰基乙酰肼及其衍生物开始合成其他不常见的杂环（如噻二唑，恶二唑，稠合杂环）和一些七元和八元杂环（如苯并二氮杂卓，奥氮平和苯并oc辛）的方法。这篇综述的主要目的是通过各种类型的反应，包括环缩合和环化反应，展示氰基乙酰肼在杂环合成中的应用。结果根据形成的杂环的类型排列，从五元，六元，七元到八元环和稠合环。这篇评论旨在涵盖截至2018年的文献，

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