Dynamic and Responsive DNA-Like Polymers,Journal of the American Chemical Society

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Dynamic and Responsive DNA-Like Polymers
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2018-10-10 , DOI: 10.1021/jacs.8b09105
Sudheendran Mavila ₁ , Brady T. Worrell ₁ , Heidi R. Culver ₁ , Trevor M. Goldman ₁ , Chen Wang ₁ , Chern-Hooi Lim ₁ , Dylan W. Domaille ₁ , Sankha Pattanayak ₁ , Matthew K. McBride ₁ , Charles B. Musgrave ₁ , Christopher N. Bowman ₁

Affiliation

The synthesis of thiolactone monomers that mimic natural nucleosides and engage in robust ring opening polymerizations (ROP) is herein described. As each repeat unit contains a thioester functional group, dynamic rearrangement of the polymer is feasible via thiol-thioester exchange, demonstrated here by depolymerization of the polymers and coalescing of two polymers of different molecular weight or chemical composition. This approach constitutes the first step toward a platform that enables for the routine synthesis of sequence controlled polymers via dynamic template directed synthesis.

中文翻译：

动态响应的类 DNA 聚合物

本文描述了模拟天然核苷并参与稳健的开环聚合 (ROP) 的硫内酯单体的合成。由于每个重复单元都包含一个硫酯官能团，聚合物的动态重排可以通过硫醇-硫酯交换实现，这里通过聚合物的解聚和两种不同分子量或化学组成的聚合物的聚结来证明。这种方法构成了通过动态模板定向合成常规合成序列控制聚合物的平台的第一步。

更新日期：2018-10-10

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