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Photonic cancer nanomedicine using the near infrared-II biowindow enabled by biocompatible titanium nitride nanoplatforms.
Nanoscale Horizons ( IF 8.0 ) Pub Date : 2018-10-29 , DOI: 10.1039/c8nh00299a
Chunmei Wang 1 , Chen Dai , Zhongqian Hu , Hongqiang Li , Luodan Yu , Han Lin , Jianwen Bai , Yu Chen
Affiliation  

Light-activated photoacoustic imaging (PAI) and photothermal therapy (PTT) using the second near-infrared biowindow (NIR-II, 1000-1350 nm) hold great promise for efficient tumor detection and diagnostic imaging-guided photonic nanomedicine. In this work, we report on the construction of titanium nitride (TiN) nanoparticles, with a high photothermal-conversion efficiency and desirable biocompatibility, as an alternative theranostic agent for NIR-II laser-excited photoacoustic (PA) imaging-guided photothermal tumor hyperthermia. Working within the NIR-II biowindow provides a larger maximum permissible exposure (MPE) and desirable penetration depth of the light, which then allows detection of the tumor to the full extent using PA imaging and complete tumor ablation using photothermal ablation, especially in deeper regions. After further surface polyvinyl-pyrrolidone (PVP) modification, the TiN-PVP photothermal nanoagents exhibited a high photothermal conversion efficiency of 22.8% in the NIR-II biowindow, and we further verified their high penetration depth using the NIR-II biowindow and their corresponding therapeutic effect on the viability of tumor cells in vitro. Furthermore, these TiN-PVP nanoparticles were developed as a contrast agent for NIR-II-activated PA imaging both in vitro and in vivo for the first time and realized efficient photothermal ablation of the tumor in vivo within both the NIR-I and NIR-II biowindows. This work not only provides a paradigm for TiN-PVP photothermal nanoagents working in the NIR-II biowindow both in vitro and in vivo, but also proves the feasibility of PAI and PTT cancer theranostics using NIR-II laser excitation.

中文翻译:

使用通过生物相容性氮化钛纳米平台实现的近红外II生物窗口的光子癌纳米医学。

使用第二个近红外生物窗口(NIR-II,1000-1350 nm)的光激活光声成像(PAI)和光热疗法(PTT)为有效的肿瘤检测和诊断成像指导的光子纳米医学提供了广阔的前景。在这项工作中,我们报告了具有高光热转换效率和理想生物相容性的氮化钛(TiN)纳米颗粒的构造,作为NIR-II激光激发光声(PA)成像引导的光热肿瘤热疗的替代治疗剂。在NIR-II生物窗口内工作可提供更大的最大允许曝光量(MPE)和理想的光穿透深度,从而允许使用PA成像在最大程度上检测肿瘤,并使用光热消融术彻底消融肿瘤,尤其是在较深的区域。经过进一步的表面聚乙烯吡咯烷酮(PVP)修饰后,TiN-PVP光热纳米剂在NIR-II生物窗口中显示出22.8%的高光热转换效率,我们进一步使用NIR-II生物窗口及其相应的方法验证了它们的高渗透深度体外对肿瘤细胞生存力的治疗作用。此外,首次将这些TiN-PVP纳米粒子开发为用于NIR-II激活的PA成像的造影剂,可在体内和体外进行成像,并在NIR-1和NIR- II生物窗户。这项工作不仅为在体外和体内在NIR-II生物窗口中工作的TiN-PVP光热纳米剂提供了范例,而且证明了使用NIR-II激光激发进行PAI和PTT癌症治疗的可行性。
更新日期:2018-10-10
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