Biodegradable 2D Fe–Al Hydroxide for Nanocatalytic Tumor‐Dynamic Therapy with Tumor Specificity,Advanced Science

当前位置： X-MOL 学术 › Adv. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Biodegradable 2D Fe–Al Hydroxide for Nanocatalytic Tumor‐Dynamic Therapy with Tumor Specificity
Advanced Science ( IF 14.3 ) Pub Date : 2018-10-09 , DOI: 10.1002/advs.201801155
Zhenbang Cao ₁ , Liang Zhang ₂ , Kang Liang ₁ , Soshan Cheong ₃ , Cyrille Boyer ₁ , J Justin Gooding ₄ , Yu Chen ₅ , Zi Gu ₁

Affiliation

Therapeutic nanocatalysis has emerged as an intriguing strategy for efficient cancer‐specific therapy, but the traditional inorganic nanocatalysts suffer from low catalytic efficiency and difficulty in biodegradation, hindering their further clinical translation. Herein, a tumor microenvironment‐triggered, biodegradable and biocompatible nanocatalyst employing 2D hydroxide nanosheet is presented, and is shown to have high catalytic capacity to efficiently produce abundant hydroxyl radicals under the tumor microenvironment and consequently kill tumor cells selectively. A polyethylene glycol (PEG)‐conjugated Fe²⁺‐containing hydroxide nanosheet is successfully constructed via a facile but efficient bottom‐up approach that concurrently realizes nanosheet synthesis and PEGylation. Importantly, the nanosheets are featured with high catalytic activity to disproportionate H₂O₂ in tumors, and consequently generate abundant hydroxyl radicals at a high reaction rate under tumorous acidic condition; the highly toxic hydroxyl radicals, as a result, cause the death of tumor cells in vitro and suppress the tumor growth in vivo without the use of any supplementary toxic agent, only with the biocompatible nanocatalysts. Meanwhile, the desirable biodegradation and biocompatibility of the hydroxide nanosheet render a high degree of safety to the organism. Therefore, this work provides the first paradigm of biodegradable 2D nanocatalytic platform with concurrently high catalytic‐therapeutic performance and biosafety for efficient tumor‐specific treatment.

中文翻译：

可生物降解的二维铁铝氢氧化物用于具有肿瘤特异性的纳米催化肿瘤动态治疗

治疗性纳米催化已成为一种有效的癌症特异性治疗的有趣策略，但传统的无机纳米催化剂催化效率低且难以生物降解，阻碍了其进一步的临床转化。在此，提出了一种采用二维氢氧化物纳米片的肿瘤微环境触发的、可生物降解和生物相容的纳米催化剂，并被证明具有高催化能力，可以在肿瘤微环境下有效产生丰富的羟基自由基，从而选择性地杀死肿瘤细胞。通过一种简单而有效的自下而上的方法成功构建了聚乙二醇（PEG）共轭的含Fe ^{2+的氢氧化物纳米片，同时实现了纳米片的合成和聚乙二醇化。}_{重要的是，纳米片对肿瘤中的H 2} O ₂歧化具有高催化活性，因此在肿瘤酸性条件下以高反应速率产生丰富的羟基自由基。因此，剧毒的羟基自由基在体外导致肿瘤细胞死亡，并在体内抑制肿瘤生长，无需使用任何补充毒性剂，仅使用生物相容性纳米催化剂。同时，氢氧化物纳米片良好的生物降解性和生物相容性为生物体提供了高度的安全性。因此，这项工作提供了可生物降解的二维纳米催化平台的第一个范例，该平台同时具有高催化治疗性能和生物安全性，可用于有效的肿瘤特异性治疗。

更新日期：2018-10-09

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11