The development of synthetic methodology allowing for a strategic incorporation of fluorine into target compounds is in a high demand in many areas of the chemical and pharmaceutical industries. In this regard, application of fluorinated chiral sulfinimine reagents, in particularly, N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimine, is one of the most general and practical approaches for preparation of compounds containing pharmacophoric fluoro-amino-keto/hydroxy moieties. This article provides a timely and comprehensive overview of the recent synthetic applications of fluorinated chiral sulfinimine reagents for asymmetric synthesis of fluoro-containing polyfunctional amino-compounds of biological interest. Where it is possible, we emphasize the synthetic versatility and practicality of the reported methods.

在化学和制药工业的许多领域中，对允许将氟战略性地掺入目标化合物中的合成方法的开发提出了很高的要求。在这方面，氟化的手性亚磺酰亚胺试剂的应用，特别是在，Ñ -叔-丁基亚磺酰基-3,3,3-三氟乙二胺是制备含有药效基团氟-氨基-酮/羟基部分的化合物的最通用和最实用的方法之一。本文提供了有关氟化手性亚氨基亚胺试剂在不对称合成具有生物学意义的含氟多官能氨基化合物的最新合成应用中的及时全面综述。在可能的情况下，我们强调已报道方法的综合多功能性和实用性。