A simple and efficient method was developed for the synthesis of 5,6-dihydropyrazin-2(1H)-one O-(tert-butyl)oximes, quinoxalin-2(1H)-one O-(tert-butyl)oximes and its derivatives from N-tert-butoxy acyl imidoyl bromide and diamines. Twenty three novel compounds were readily synthesized using this procedure in excellent yields. The products possessed Z-stereochemistry with regard to the CN double bond. In these reactions, the amino group first attacked an imidoyl carbon of the N-tert-butoxy acyl imidoyl bromide in order to obtain the Z-intermediate; then another amino group attacked the carbonyl carbon of the intermediate. The rate of intramolecular cyclization of the intermediate was dependent on the position of the diamino groups.

建立了一种简单有效的合成5,6-二氢吡嗪-2（1 H）-一O-（叔丁基）肟，喹喔啉-2（1 H）-一O-（叔丁基）肟的方法。和其衍生物从ñ -叔丁氧基酰亚胺酰基溴和二胺。使用该方法很容易合成了23种新型化合物，收率很高。产物具有关于C N双键的Z-立体化学。在这些反应中，氨基第一攻击的亚氨碳ñ -叔丁氧基酰亚胺溴化以获得Z-中间体; 然后另一个氨基攻击中间体的羰基碳。中间体的分子内环化速率取决于二氨基的位置。