Four-component acyloxy-trifluoromethylation of arylalkenes mediated by a photoredox catalyst,Organic & Biomolecular Chemistry

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Four-component acyloxy-trifluoromethylation of arylalkenes mediated by a photoredox catalyst
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-10-09 , DOI: 10.1039/c8ob02239a
Xiaocong Zhou _{1,

2,

3,

4,

5} , Guijie Li _{1,

2,

3,

4} , Zongzhou Shao _{1,

2,

3,

4} , Kun Fang _{1,

2,

3,

4} , Hongjun Gao _{3,

4,

5,

6} , Yuanqiang Li _{3,

4,

5,

6} , Yuanbin She _{1,

2,

3,

4}

Affiliation

A four-component intermolecular trifluoromethylation–acyloxylation of arylalkenes induced by visible light has been developed in the presence of the photoredox catalyst Ru(bpy)₃(PF₆)₂ under mild reaction conditions. A new Umemoto's reagent was used as a trifluoromethyl radical source, and this redox neutral reaction demonstrated good functional group tolerance for aryl alkenes with high yields up to 91%. The detailed reaction process was investigated based on control, deuterium and O¹⁸-labeling experiments to support that N,N-dimethylformamide (DMF)/H₂O acted as an acyloxyl source.

中文翻译：

光氧化还原催化剂介导的芳基烯烃的四组分酰氧基-三氟甲基化

在光氧化还原催化剂Ru（bpy）₃（PF ₆）_2的存在下，在温和的反应条件下，开发了由可见光诱导的芳烃的四组分分子间三氟甲基化-酰氧基化反应。一种新的梅本试剂用作三氟甲基自由基的来源，该氧化还原中性反应显示出对芳基烯烃具有良好的官能团耐受性，收率高达91％。基于对照，氘和O ¹⁸标记实验研究了详细的反应过程，以支持N，N-二甲基甲酰胺（DMF）/ H ₂ O充当酰氧基源。

更新日期：2018-12-20

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