Third generation antibody discovery methods: in silico rational design,Chemical Society Reviews

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Third generation antibody discovery methods: in silico rational design
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-10-09 00:00:00 , DOI: 10.1039/c8cs00523k
Pietro Sormanni _{1,

2,

3,

4,

5} , Francesco A. Aprile _{1,

2,

3,

4,

5} , Michele Vendruscolo _{1,

2,

3,

4,

5}

Affiliation

Owing to their outstanding performances in molecular recognition, antibodies are extensively used in research and applications in molecular biology, biotechnology and medicine. Recent advances in experimental and computational methods are making it possible to complement well-established in vivo (first generation) and in vitro (second generation) methods of antibody discovery with novel in silico (third generation) approaches. Here we describe the principles of computational antibody design and review the state of the art in this field. We then present Modular, a method that implements the rational design of antibodies in a modular manner, and describe the opportunities offered by this approach.

中文翻译：

第三代抗体发现方法：计算机合理设计

由于其在分子识别方面的出色表现，抗体被广泛用于分子生物学，生物技术和医学的研究和应用。实验和计算方法的最新进展使得有可能用新型计算机模拟（第三代）方法来补充成熟的体内（第一代）和体外（第二代）抗体发现方法。在这里，我们描述了计算抗体设计的原理，并回顾了该领域的最新技术。然后，我们介绍模块化，一种以模块化方式实现抗体合理设计的方法，并描述这种方法提供的机会。

更新日期：2018-10-09

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