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Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-10-09 00:00:00 , DOI: 10.1039/c8cc05175e Hardev Singh 1, 2, 3, 4 , Seo Jin Kim 4, 5, 6, 7 , Dong Hoon Kang 4, 8, 9, 10 , Hye-Ri Kim 4, 5, 6, 7 , Amit Sharma 1, 2, 3, 4 , Won Young Kim 1, 2, 3, 4 , Chulhun Kang 4, 5, 6, 7 , Jong Seung Kim 1, 2, 3, 4
Chemical Communications ( IF 4.3 ) Pub Date : 2018-10-09 00:00:00 , DOI: 10.1039/c8cc05175e Hardev Singh 1, 2, 3, 4 , Seo Jin Kim 4, 5, 6, 7 , Dong Hoon Kang 4, 8, 9, 10 , Hye-Ri Kim 4, 5, 6, 7 , Amit Sharma 1, 2, 3, 4 , Won Young Kim 1, 2, 3, 4 , Chulhun Kang 4, 5, 6, 7 , Jong Seung Kim 1, 2, 3, 4
Affiliation
Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.
中文翻译:
甘草次酸作为肝细胞靶向单位,用于具有增强的细胞类型选择性的抗癌药物递送系统†
在本文中,我们报告了甘草次酸(GA)作为肝细胞癌(HCC)的主动靶向配体的潜力,可用于开发基于小分子方法的诊断/治疗方法。我们的初步结果表明,GA与诊断/治疗对应物的结合显着增强了其HCC靶向能力和出色的治疗功效。
更新日期:2018-10-09
中文翻译:
甘草次酸作为肝细胞靶向单位,用于具有增强的细胞类型选择性的抗癌药物递送系统†
在本文中,我们报告了甘草次酸(GA)作为肝细胞癌(HCC)的主动靶向配体的潜力,可用于开发基于小分子方法的诊断/治疗方法。我们的初步结果表明,GA与诊断/治疗对应物的结合显着增强了其HCC靶向能力和出色的治疗功效。