A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome markers†,Food & Function

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A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome markers†
Food & Function ( IF 5.1 ) Pub Date : 2018-10-08 00:00:00 , DOI: 10.1039/c8fo01323c
Daniel Martínez-Maqueda _{1,

2,

3,

4,

5} , Belén Zapatera _{1,

2,

3,

4,

5} , Angélica Gallego-Narbón _{1,

2,

3,

4,

5} , M. Pilar Vaquero _{1,

2,

3,

4,

5} , Fulgencio Saura-Calixto _{1,

2,

3,

4,

5} , Jara Pérez-Jiménez _{1,

2,

3,

4,

5}

Affiliation

Grape polyphenols have shown a promising role in the modulation of metabolic syndrome (MetS), mostly in animal models. However, clinical studies are scarce and they usually only consider a fraction of polyphenols, ignoring the non-extractable polyphenols (high molecular weight compounds or associated with macromolecules such as dietary fibre). This study aimed at evaluating the effect of grape pomace, rich in both extractable and non-extractable polyphenols, on markers of MetS. Fifty subjects (22 women) aged 20–65 with at least two MetS factors were randomly assigned to the product (daily dose of 8 g of dried grape pomace) or to the control group in a 6 week crossover design with a 4 week wash-out. Samples were collected at the beginning and at the end of both periods; half of the participants were subjected to an oral glucose tolerance test at the beginning and the end of the supplementation period. Grape pomace supplementation significantly improved fasting insulinaemia (p < 0.01), without affecting other cardiometabolic risk parameters. A tendency towards an improvement in postprandial insulinaemia was observed, particularly in those subjects with higher fasting insulin levels. Therefore, supplementation with grape pomace may be a strategy for improving insulin sensitivity in subjects at high cardiometabolic risk.

中文翻译：

对有心脏代谢风险的受试者补充葡萄果渣6周可改善胰岛素敏感性，而不会影响其他代谢综合征指标†

葡萄多酚在代谢综合征（MetS）的调节中已显示出有希望的作用，主要是在动物模型中。但是，临床研究很少，他们通常只考虑多酚的一部分，而忽略了不可提取的多酚（高分子量化合物或与大分子相关的食物纤维等）。这项研究旨在评估富含可提取和不可提取的多酚的葡萄渣对MetS标记物的影响。50名年龄在20-65岁且至少具有两个MetS因子的受试者（22例女性）被随机分配至产品（每日剂量为8 g葡萄干果渣干）或对照组，采用6周交叉设计，并进行4周冲洗，出去。在这两个时期的开始和结束时都收集了样品。在补充期的开始和结束时，一半的参与者接受了口服葡萄糖耐量测试。补充葡萄果渣可显着改善空腹胰岛素血症（p <0.01），而不会影响其他心脏代谢风险参数。观察到餐后胰岛素血症有改善的趋势，特别是在那些空腹胰岛素水平较高的受试者中。因此，补充葡萄果渣可能是改善心脏代谢风险高的受试者对胰岛素敏感性的一种策略。

更新日期：2018-10-08

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