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Stimuli-Responsive Therapeutic Metallodrugs
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-10-09 00:00:00 , DOI: 10.1021/acs.chemrev.8b00209 Xiaohui Wang 1 , Xiaoyong Wang 2 , Suxing Jin 2 , Nafees Muhammad 3 , Zijian Guo 4
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-10-09 00:00:00 , DOI: 10.1021/acs.chemrev.8b00209 Xiaohui Wang 1 , Xiaoyong Wang 2 , Suxing Jin 2 , Nafees Muhammad 3 , Zijian Guo 4
Affiliation
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The success of platinum-based anticancer agents has motivated the exploration of novel metal-based drugs for several decades, whereas problems such as drug-resistance and systemic toxicity hampered their clinical applications and efficacy. Stimuli-responsiveness of some metal complexes offers a good opportunity for designing site-specific prodrugs to maximize the therapeutic efficacy and minimize the side effect of metallodrugs. This review presents a comprehensive and up-to-date overview on the therapeutic stimuli-responsive metallodrugs that have appeared in the past two decades, where stimuli such as redox, pH, enzyme, light, temperature, and so forth were involved. The compounds are classified into three major categories based on the nature of stimuli, that is, endo-stimuli-responsive metallodrugs, exo-stimuli-responsive metallodrugs, and dual-stimuli-responsive metallodrugs. Representative examples of each type are discussed in terms of structure, response mechanism, and potential medical applications. In the end, future opportunities and challenges in this field are tentatively proposed. With diverse metal complexes being introduced, the foci of this review are pointed to platinum and ruthenium complexes.
中文翻译：
刺激响应性金属药物
铂基抗癌药的成功推动了几十年来新型金属基药物的探索，而耐药性和全身毒性等问题却阻碍了它们的临床应用和疗效。一些金属配合物的刺激反应性为设计位点特异性前药提供了一个很好的机会，以最大化治疗功效并最大程度地减少金属药物的副作用。这篇综述对过去二十年来出现的具有治疗反应性的金属药物进行了全面而最新的综述，其中涉及到诸如氧化还原，pH，酶，光，温度等刺激。根据刺激物的性质，这些化合物可分为三大类，即对内刺激有反应的金属药物，对外刺激有反应的金属药物，以及对双刺激有反应的金属药物。每种类型的代表性示例均在结构，响应机制和潜在医学应用方面进行了讨论。最后，初步提出了该领域的未来机遇与挑战。随着各种金属配合物的引入，本文的重点是铂和钌配合物。
更新日期：2018-10-09
中文翻译：
刺激响应性金属药物
铂基抗癌药的成功推动了几十年来新型金属基药物的探索，而耐药性和全身毒性等问题却阻碍了它们的临床应用和疗效。一些金属配合物的刺激反应性为设计位点特异性前药提供了一个很好的机会，以最大化治疗功效并最大程度地减少金属药物的副作用。这篇综述对过去二十年来出现的具有治疗反应性的金属药物进行了全面而最新的综述，其中涉及到诸如氧化还原，pH，酶，光，温度等刺激。根据刺激物的性质，这些化合物可分为三大类，即对内刺激有反应的金属药物，对外刺激有反应的金属药物，以及对双刺激有反应的金属药物。每种类型的代表性示例均在结构，响应机制和潜在医学应用方面进行了讨论。最后，初步提出了该领域的未来机遇与挑战。随着各种金属配合物的引入，本文的重点是铂和钌配合物。
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