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Collaborative Evaluation of Commercially Available Automated Powder Dispensing Platforms for High-Throughput Experimentation in Pharmaceutical Applications
Organic Process Research & Development ( IF 3.4 ) Pub Date : 2018-10-09 00:00:00 , DOI: 10.1021/acs.oprd.8b00259
Matthew N. Bahr 1 , David B. Damon 2 , Simon D. Yates 3 , Alexander S. Chin 4 , J. David Christopher 5 , Samuel Cromer 1, 6 , Nicholas Perrotto 7 , Jorge Quiroz 8 , Victor Rosso 9
Affiliation  

Many workflows in Pharmaceutical R&D involve the manipulation of defined amounts of powders. Automated powder dispensing platforms are currently available; however, these existing technologies do not meet the requirements for every high-throughput experimentation powder dispensing application. A Working Group (WG) composed of pharmaceutical researchers within the Enabling Technologies Consortium (ETC) evaluated automated platforms commercially available from three manufacturers using an objective, systematic testing protocol. This paper describes the selection of powders and testing conditions used in this evaluation, and it assesses the impact that the powders, testing conditions, equipment environment, and other factors had on the performance of the selected platforms.

中文翻译:

用于制药领域高通量实验的市售自动粉末分配平台的协同评估

制药研发中的许多工作流程都涉及一定量粉末的操作。自动化粉末分配平台目前可用;但是,这些现有技术不能满足每种高通量实验粉末分配应用的要求。由Enabling Technologies Consortium(ETC)中的药物研究人员组成的工作组(WG)使用客观的系统测试协议评估了可从三个制造商处购买的自动化平台。本文介绍了用于评估的粉末的选择和测试条件,并评估了粉末,测试条件,设备环境和其他因素对所选平台性能的影响。
更新日期:2018-10-09
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