Copper‐Catalyzed Radical Cross‐Coupling of Redox‐Active Oxime Esters, Styrenes, and Boronic Acids,Angewandte Chemie International Edition

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Copper‐Catalyzed Radical Cross‐Coupling of Redox‐Active Oxime Esters, Styrenes, and Boronic Acids
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-10-19 , DOI: 10.1002/anie.201809820
Xiao‐Ye Yu ₁ , Quan‐Qing Zhao ₁ , Jun Chen ₁ , Jia‐Rong Chen ₁ , Wen‐Jing Xiao _{1,

2}

Affiliation

A visible‐light‐driven, copper‐catalyzed three‐component radical cross‐coupling of oxime esters, styrenes, and boronic acids has been developed. Key steps of this protocol involve catalytic generation of an iminyl radical from a redox‐active oxime ester and subsequent C−C bond cleavage to generate a cyanoalkyl radical. Upon its addition to styrene, the newly formed benzylic radical undergoes coupling with a boronic‐acid‐derived ArCu^II complex to achieve 1,1‐diarylmethane‐containing alkylnitriles.

中文翻译：

铜催化的氧化还原活性肟酯，苯乙烯和硼酸的自由基交叉偶联

已经开发了一种由可见光驱动，铜催化的肟酯，苯乙烯和硼酸的三组分自由基交叉偶联反应。该协议的关键步骤涉及从氧化还原活性肟酯催化生成亚胺基，然后进行C-C键裂解，生成氰基烷基。在将其添加到苯乙烯中后，新形成的苄基与硼酸衍生的ArCu ^II配合物偶联，从而获得含1,1-二芳基甲烷的烷基腈。

更新日期：2018-10-19

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