Heterogeneous Esterification from α-Hydroxy Ketone and Alcohols through a Tandem Oxidation Process over a Hydrotalcite-Supported Bimetallic Catalyst,Organic Process Research & Development

当前位置： X-MOL 学术 › Org. Process Res. Dev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Heterogeneous Esterification from α-Hydroxy Ketone and Alcohols through a Tandem Oxidation Process over a Hydrotalcite-Supported Bimetallic Catalyst
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2018-10-08 00:00:00 , DOI: 10.1021/acs.oprd.8b00265
Xu Meng ₁ , Xiuru Bi ₁ , Gexin Chen ₁ , Baohua Chen ₂ , Peiqing Zhao ₁

Affiliation

Heterogeneous aerobic oxidative esterification between α-hydroxy ketone and alcohols catalyzed by a hydrotalcite-supported bimetallic catalyst (CuMn/HT) using O₂ as a green oxidant was achieved. Recyclable CuMn/HT exhibits high catalytic activity due to increased content of oxygen vacancies and a newly generated CuMn₂O₄ crystal phase. This clean esterification proceeds through a tandem oxidation process in the absence of any additives and ligands and affords α-keto esters in good to excellent yields. Moreover, the catalytic system tolerates complicated bioactive molecules as raw materials and can be performed on a multigram scale.

中文翻译：

在水滑石负载的双金属催化剂上通过串联氧化法从α-羟基酮和醇进行异构化酯化反应

以水滑石为载体的双金属催化剂（CuMn / HT），以O ₂为绿色氧化剂，催化了α-羟基酮与醇类之间的异质好氧氧化酯化反应。由于氧空位含量的增加和新生成的CuMn ₂ O ₄晶相，可回收的CuMn / HT表现出较高的催化活性。这种清洁的酯化反应在不存在任何添加剂和配体的情况下通过串联氧化过程进行，并以良好或极好的收率提供了α-酮基酯。此外，该催化系统可以耐受复杂的生物活性分子作为原材料，并且可以在数克规模上进行。

更新日期：2018-10-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11