The co-adsorption of mixed nonionic surfactant and imidazolium-based ionic liquid, Triton X100 (TX100), with 1-cetyl-3-methylimidazolium bromide (C₁₆mimBr) adsorbed onto the surface of magnetic halloysite nanotubes (MHNTs) was used as an efficient adsorbent for simultaneous determination of amlodipine and nimodipine in urine. The designed adsorbent was characterized by TEM, TGA, FTIR, and DLS analysis methods. All the parameters that influence the extraction efficiency are optimized with the aid of response surface methodology (RSM). The effects of nonionic surfactant TX100 with different structures of ionic-liquid-coated MHNTs were investigated. Under optimum conditions, extraction recoveries of amlodipine and nimodipine were in the range of 73.8–81.2 and 94.3–96.1%, with RSDs (n = 3) of 2.6–5.5% in spiked urine samples, respectively. The adsorption mechanism principal of mixed hemimicelles was discussed in this study. The limit of detection obtained for analytes was < 0.002 μg·mL⁻¹. To our knowledge, this was the first attempt using a mixed hemimicelle solid-phase extraction (SPE) based on MHNTs and nonionic surfactant and imidazolium-based ionic liquid for the simultaneous determination of amlodipine and nimodipine in biological samples.

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将混合的非离子表面活性剂和咪唑基离子液体Triton X100（TX100）与1-十六烷基-3-甲基咪唑鎓溴化物（C ₁₆ mimBr）共同吸附在磁性埃洛石纳米管（MHNTs）的表面上同时测定尿液中氨氯地平和尼莫地平的高效吸附剂。通过TEM，TGA，FTIR和DLS分析方法对设计的吸附剂进行了表征。借助响应面法（RSM）对影响萃取效率的所有参数进行了优化。研究了非离子表面活性剂TX100对离子液体包覆MHNTs结构的影响。在最佳条件下，氨氯地平和尼莫地平的提取回收率在73.8–81.2和94.3–96.1％的范围内，而RSDs（n = 3）在加标尿液样本中分别为2.6–5.5％。本研究探讨了混合半胶束的吸附机理。分析物的检出限为<0.002μg·mL ^-1。据我们所知，这是首次尝试使用基于MHNT，非离子表面活性剂和咪唑鎓类离子液体的混合半胶束固相萃取（SPE）同时测定生物样品中的氨氯地平和尼莫地平。

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