Impact of infrared radiation on UVB-induced skin tumourigenesis in wild type C57BL/6 mice†,Photochemical & Photobiological Sciences

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Impact of infrared radiation on UVB-induced skin tumourigenesis in wild type C57BL/6 mice†
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2018-10-08 00:00:00 , DOI: 10.1039/c8pp00118a
Susanne Kimeswenger _{1,

2,

3} , Barbara Sterniczky _{1,

2,

3} , Anne Kramer _{2,

3,

4} , Katharina Tillmann _{2,

3,

4} , Jutta Gamper _{2,

3,

5,

6,

7} , Dagmar Foedinger _{1,

2,

3} , Peter Petzelbauer _{1,

2,

3} , Christian Jantschitsch _{1,

2,

3}

Affiliation

Although infrared radiation (IR) represents more than 50% of the solar radiation reaching the Earth's surface, this waveband has been hardly investigated in terms of tumourigenesis. The objective of the present study was to investigate the influence of IR on ultraviolet B (UVB)-induced carcinogenesis in male and female wild type mice. For this purpose, male and female C57BL/6N mice were subjected to a long-term irradiation protocol. Mice were irradiated once neonatally and from the age of eight weeks for 36 weeks with a cumulative dose of 576 kJ m⁻² UVB and/or 78 895 kJ m⁻² IR. In order to resemble natural sun irradiation, exposure to physiological doses of UVB and IR was performed simultaneously. Mice were screened for arising lesions twice a week. Lesions were excised and histologically diagnosed. Kaplan–Meier analyses were carried out and lesion counts and cumulated hazard rates for the development of lesions in the UVB and IR + UVB-exposed groups in male and female mice were compared. We found that IR-exposure did not change the number of epithelial malignant tumours in UVB-exposed wild type mice. In combination with IR there was a tendency of more tumours with increased malignancy: 23 vs. seven spindle cell shaped sarcomas and seven vs. two MelanA+/S100+ tumours in groups of 35 C57BL/6 mice. IR did not influence UVB-induced carcinogenesis differently in male and female mice. However, comparing UVB and sham irradiated animals irrespective of IR exposure, UVB-induced non-epithelial tumours arose significantly earlier in male mice than in female mice.

中文翻译：

红外辐射对野生型C57BL / 6小鼠UVB诱导的皮肤肿瘤发生的影响†

尽管红外辐射（IR）占到达地球表面的太阳辐射的50％以上，但该波段几乎尚未从肿瘤发生方面进行研究。本研究的目的是研究红外线对雄性和雌性野生型小鼠中紫外线B（UVB）诱导的致癌作用的影响。为此，对雄性和雌性C57BL / 6N小鼠进行了长期照射。从新生开始，从八周龄开始对小鼠进行一次辐射，历时36周，累计剂量为576 kJ m ^-2 UVB和/或78 895 kJ m ^-2红外线为了类似于自然阳光照射，同时进行了生理剂量的UVB和IR暴露。每周两次对小鼠进行筛查是否出现病灶。切除病灶并进行组织学诊断。进行了Kaplan–Meier分析，并比较了雄性和雌性小鼠中UVB和IR + UVB暴露组中病变发展的病变计数和累积危害率。我们发现红外线暴露并没有改变暴露于UVB的野生型小鼠中上皮恶性肿瘤的数量。与IR结合有更多的肿瘤具有增加的恶性的倾向：23与7个梭形细胞形肉瘤和7与35只C57BL / 6小鼠的组中有2个MelanA + / S100 +肿瘤。IR在雄性和雌性小鼠中对UVB诱导的致癌作用没有不同的影响。但是，比较UVB和假辐射动物，无论是否暴露于IR，在雄性小鼠中，UVB诱导的非上皮性肿瘤的发生明显早于雌性小鼠。

更新日期：2018-10-08

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