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Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men†
Food & Function ( IF 5.1 ) Pub Date : 2018-10-08 00:00:00 , DOI: 10.1039/c8fo00971f Ying Zhang 1, 2, 3, 4, 5 , Jin Liu 6, 7, 8, 9, 10 , Xiao-qiang Chen 1, 2, 3, 4, 5 , C.-Y. Oliver Chen 6, 7, 8, 9, 11
Food & Function ( IF 5.1 ) Pub Date : 2018-10-08 00:00:00 , DOI: 10.1039/c8fo00971f Ying Zhang 1, 2, 3, 4, 5 , Jin Liu 6, 7, 8, 9, 10 , Xiao-qiang Chen 1, 2, 3, 4, 5 , C.-Y. Oliver Chen 6, 7, 8, 9, 11
Affiliation
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Coenzyme Q10 (CoQ10) exerts its functions in the body through the ability of its benzoquinone head group to accept and donate electrons. The primary functions are to relay electrons for ATP production in the electron transport chain and to act as an important lipophilic antioxidant. Ubiquinone, the oxidized form of CoQ10, is commonly formulated in commercial supplements, and it must be reduced to ubiquinol to exert CoQ10's functions after consumption. Thus, we aimed to examine whether as compared to ubiquinone, ubiquinol would be more effective to enhance the CoQ10 status in older men. We conducted a double-blind, randomized, crossover trial with two 2-week intervention phases and a 2-week washout between crossovers. Ten eligible older men were randomized to consume either the ubiquinol or ubiquinone supplement at a dose of 200 mg d−1 with one of the main meals. A total of 4 blood samples were collected after an overnight fast for the determination of ubiquinone and ubiquinol in plasma and PBMC and the assessment of FRAP, total thiol, and malondialdehyde (MDA) in plasma and ATP in PBMC. After 2 weeks of the supplementation, the ubiquinol supplement significantly increased plasma ubiquinone 1.7 fold from 0.2 to 0.6 μmol L−1 and total CoQ10 (the sum of 2 forms) 1.5 fold from 1.3 to 3.4 μmol L−1 (p < 0.05) and tended to increase the plasma ubiquinol status 1.5 fold from 1.1 to 2.8 μmol L−1, but did not alter the ratio of ubiquinol to total CoQ10. The ubiquinone supplement insignificantly increases plasma ubiquinol, ubiquinone, and total CoQ10 and did not affect the ratio. Of 10 subjects, six were more responsive to the ubiquinol supplement and 2 were more so to the ubiquinone. The supplementation of both CoQ10 forms did not alter the CoQ10 status in PBMC. FRAP, total thiol, and MDA in plasma and ATP in PBMC were not changed during the intervention. The significant increase in plasma CoQ10 status observed after the 2-week supplementation suggested that ubiquinol appeared to be a better supplemental form to enhance the CoQ10 status than ubiquinone in older men. Neither ubiquinol nor ubiquinone supplement affected the measured biomarkers of oxidative stress.
中文翻译：
泛醇优于泛醌，可增强老年男性的辅酶Q10状况†
辅酶Q10（CoQ10）通过其苯醌醌基团接受和捐赠电子的能力在体内发挥其功能。主要功能是中继电子以在电子传输链中产生ATP，并起重要的亲脂性抗氧化剂的作用。泛醌，CoQ10的氧化形式，通常在商业补品中配制，食用后必须还原成泛醇才能发挥CoQ10的功能。因此，我们旨在检查与泛醌相比，泛醇是否可以更有效地提高老年男性的CoQ10状况。我们进行了一项双盲，随机，交叉试验，分为两个2周的干预阶段，两次交叉之间的洗脱期为2周。随机将十名合格的老年男性以200 mg d的剂量服用泛醇或泛醌补充剂-1点主菜之一。整夜禁食后，总共收集了4个血液样本，用于测定血浆和PBMC中的泛醌和泛醇，以及评估血浆中FRAP，总硫醇和丙二醛（MDA）和PBMC中的ATP。补充2周后，泛醇补充剂使血浆泛醌含量从0.2到0.6μmolL -1显着增加1.7倍，总CoQ10（两种形式的总和）从1.3到3.4μmolL -1增加1.5倍（ p <0.05），倾向于使血浆泛醇状态从1.1升至2.8μmolL -1增加1.5倍，但并未改变泛醇与总辅酶Q10的比例。泛醌补充剂不会显着增加血浆泛醇，泛醌和总辅酶Q10的含量，并且不会影响该比例。在10名受试者中，有6名对泛醇补充剂的反应更强，而2名对泛醌的反应更高。两种CoQ10形式的补充都不会改变PBMC中的CoQ10状态。干预期间血浆中的FRAP，总硫醇和MDA以及PBMC中的ATP均未改变。补充2周后，血浆CoQ10的状态显着增加，这表明在老年男性中，泛醇似乎是一种比Coquinone更好的补充CoQ10的状态。泛醇和泛醌补充剂均不会影响所测得的氧化应激生物标志物。
更新日期：2018-10-08
中文翻译：
泛醇优于泛醌，可增强老年男性的辅酶Q10状况†
辅酶Q10（CoQ10）通过其苯醌醌基团接受和捐赠电子的能力在体内发挥其功能。主要功能是中继电子以在电子传输链中产生ATP，并起重要的亲脂性抗氧化剂的作用。泛醌，CoQ10的氧化形式，通常在商业补品中配制，食用后必须还原成泛醇才能发挥CoQ10的功能。因此，我们旨在检查与泛醌相比，泛醇是否可以更有效地提高老年男性的CoQ10状况。我们进行了一项双盲，随机，交叉试验，分为两个2周的干预阶段，两次交叉之间的洗脱期为2周。随机将十名合格的老年男性以200 mg d的剂量服用泛醇或泛醌补充剂-1点主菜之一。整夜禁食后，总共收集了4个血液样本，用于测定血浆和PBMC中的泛醌和泛醇，以及评估血浆中FRAP，总硫醇和丙二醛（MDA）和PBMC中的ATP。补充2周后，泛醇补充剂使血浆泛醌含量从0.2到0.6μmolL -1显着增加1.7倍，总CoQ10（两种形式的总和）从1.3到3.4μmolL -1增加1.5倍（ p <0.05），倾向于使血浆泛醇状态从1.1升至2.8μmolL -1增加1.5倍，但并未改变泛醇与总辅酶Q10的比例。泛醌补充剂不会显着增加血浆泛醇，泛醌和总辅酶Q10的含量，并且不会影响该比例。在10名受试者中，有6名对泛醇补充剂的反应更强，而2名对泛醌的反应更高。两种CoQ10形式的补充都不会改变PBMC中的CoQ10状态。干预期间血浆中的FRAP，总硫醇和MDA以及PBMC中的ATP均未改变。补充2周后，血浆CoQ10的状态显着增加，这表明在老年男性中，泛醇似乎是一种比Coquinone更好的补充CoQ10的状态。泛醇和泛醌补充剂均不会影响所测得的氧化应激生物标志物。
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