Biomimetic Nanoemulsions for Oxygen Delivery In Vivo,Advanced Materials

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Biomimetic Nanoemulsions for Oxygen Delivery In Vivo
Advanced Materials ( IF 27.4 ) Pub Date : 2018-10-08 , DOI: 10.1002/adma.201804693
Jia Zhuang ₁ , Man Ying ₁ , Kevin Spiekermann ₁ , Maya Holay ₁ , Yue Zhang ₁ , Fang Chen ₁ , Hua Gong ₁ , Joo Hee Lee ₁ , Weiwei Gao ₁ , Ronnie H Fang ₁ , Liangfang Zhang ₁

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Blood transfusion is oftentimes required for patients suffering from acute trauma or undergoing surgical procedures in order to help maintain the body's oxygen levels. The continued demand worldwide for blood products is expected to put significant strain on available resources and infrastructure. Unfortunately, efforts to develop viable alternatives to human red blood cells for transfusion are generally unsuccessful. Here, a hybrid natural–synthetic nanodelivery platform that combines the biocompatibility of the natural RBC membrane with the oxygen‐carrying ability of perfluorocarbons is reported. The resulting formulation can be stored long‐term and exhibits a high capacity for oxygen delivery, helping to mitigate the effects of hypoxia in vitro. In an animal model of hemorrhagic shock, mice are resuscitated at an efficacy comparable to whole blood infusion. By leveraging the advantageous properties of its constituent parts, this biomimetic oxygen delivery system may have the potential to address a critical need in the clinic.

中文翻译：

用于体内供氧的仿生纳米乳液

遭受急性创伤或接受外科手术的患者通常需要输血，以帮助维持体内的氧气水平。全球对血液制品的持续需求预计将对现有资源和基础设施造成巨大压力。不幸的是，开发人类红细胞输血的可行替代品的努力通常不成功。在此，报道了一种混合天然-合成纳米递送平台，该平台结合了天然红细胞膜的生物相容性和全氟化碳的携氧能力。所得制剂可以长期保存，并具有较高的供氧能力，有助于减轻体外缺氧的影响。在失血性休克的动物模型中，小鼠的复苏效果与输注全血相当。通过利用其组成部分的有利特性，这种仿生氧气输送系统可能有潜力满足临床的关键需求。

更新日期：2018-10-08

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