This study explored the effects of co-composting of lincomycin mycelia dregs (LMDs) with furfural slag on variations in antibiotic resistance genes (ARGs) and the bacterial community. The results showed that more than 99% lincomycin was reduced after composting. Moreover, the total absolute and relative abundance of ARGs increased by 180 and 5 times, respectively. The gene lnuA was detected in the LMDs compost and it was proved to participate in lincomycin biodegradation based on the analysis of Pearson’s correlation and the lincomycin degradation byproducts. Redundancy analysis showed the succession of the bacterial community had a greater influence than the environmental parameters (residual lincomycin, C/N, pH and temperature) on the variation of ARGs during composting. Composting was not effective in reducing most of the ARGs and intI1 and thus the LMDs compost is dangerous to the ecological environment.

这项研究探讨了林可霉素菌丝残渣（LMDs）与糠醛渣共堆肥对抗生素抗性基因（ARGs）和细菌群落变化的影响。结果表明，堆肥后林可霉素减少了99％以上。而且，ARG的总绝对和相对丰度分别增加了180倍和5倍。lnuA基因在皮尔逊相关性和林可霉素降解副产物的分析基础上，在LMDs堆肥中检测到了LMP，并证明其参与了林可霉素的生物降解。冗余度分析表明，堆肥过程中细菌群落的演替对ARGs的变化比环境参数（残留的林可霉素，C / N，pH和温度）的影响更大。堆肥不能有效地减少大多数ARGs和intI1，因此LMDs堆肥对生态环境是危险的。