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Gene Dysfunction Mediates Immune Response to Dopaminergic Degeneration in Parkinson's Disease.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-10-18 , DOI: 10.1021/acschemneuro.8b00373
Zhigang Jiao 1, 2 , Wenlong Zhang 3 , Chaojun Chen 4 , Xiaoqin Zhu 5 , Xiang Chen 3 , Miaomiao Zhou 3 , Guoyou Peng 3 , Hanqun Liu 3 , Jiewen Qiu 3 , Yuwan Lin 3 , Shuxuan Huang 3 , Mingshu Mo 3 , Xinling Yang 6 , Shaogang Qu 1, 2 , Pingyi Xu 3
Affiliation  

Many publications reported that genetic dysfunction mediates abnormal immune responses in the brain, which is important for the development of neurodegenerative diseases, especially for Parkinson's disease (PD). This immune disorder results in subsequent inflammatory reaction, which stimulates microglia or other immune cells to secrete cytokines and chemokines and disturbs the proportion of peripheral blood lymphocyte subsets contributing to dopaminergic (DA) neuron apoptosis. Furthermore, the abnormal immune related signal pathways caused by genetic variants promote chronic inflammation destroying the blood-brain barrier, which allows infiltration of different molecules and blood cells into the central nervous system (CNS) exerting toxicity on DA neurons. As a result, the inflammatory reaction in the CNS accelerates the progression of Parkinson's disease and promotes α-synuclein aggregation and diffusion among DA neurons in the procession of Parkinson's disease. Thus, for disease evaluation, the genetic mediated abnormal immune response in PD may be assessed based on the multiple immune molecules and inflammatory factors, as well as the ratio of lymphocyte subsets from PD patient's peripheral blood as potential biomarkers.

中文翻译:

基因功能异常介导对帕金森氏病中多巴胺能变性的免疫反应。

许多出版物报道遗传功能障碍介导了大脑中异常的免疫反应,这对于神经退行性疾病的发展,特别是对帕金森氏病(PD)而言很重要。这种免疫疾病会导致随后的炎症反应,从而刺激小胶质细胞或其他免疫细胞分泌细胞因子和趋化因子,并扰乱导致多巴胺能(DA)神经元凋亡的外周血淋巴细胞亚群的比例。此外,由基因变异引起的异常的与免疫有关的信号通路促进了慢性炎症,破坏了血脑屏障,从而使不同的分子和血细胞渗透到中枢神经系统(CNS)中,从而对DA神经元产生毒性。因此,中枢神经系统的炎症反应加速了帕金森氏病的发展,并促进了帕金森氏病发展过程中DA神经元之间的α-突触核蛋白聚集和扩散。因此,对于疾病评估,可以基于多种免疫分子和炎性因子,以及来自PD患者外周血淋巴细胞亚群的比率作为潜在的生物标记物,评估PD中遗传介导的异常免疫反应。
更新日期:2018-10-05
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