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Transformation of biomanufacturing by single-use systems and technology
Current Opinion in Chemical Engineering ( IF 8.0 ) Pub Date : 2018-10-05 , DOI: 10.1016/j.coche.2018.09.006
Gregory T Frank

Biomanufacturing has been and continues to be transformed by the rapid innovation and adoption of single use technology (SUT). SUT has changed how bioprocesses are designed, scaled, operated, controlled, and the speed at which new technology can be incorporated into biomanufacturing. We are continually seeing advances in single use bioreactors, mixing vessels, harvest technology, and downstream bioprocess equipment. This transformation has not been limited to bioprocess equipment. In this contribution, a summary of how SUT is rapidly transforming bioprocesses and the facilities they operate in will be discussed, including SUT enabled bioprocess intensification through high cell density perfusion and continuous biomanufacturing processes. Examples of how SUT has opened up new approaches to achieving regulatory and bioprocess requirements resulting in simplified, less costly facilities to build and to operate will be presented.



中文翻译:

一次性系统和技术的生物制造转型

快速创新和一次性使用技术(SUT)的采用已经使生物制造业发生了变化,并将继续发生变化。SUT改变了生物过程的设计,规模,操作,控制方式以及将新技术整合到生物制造中的速度。我们不断看到一次性生物反应器,混合容器,收获技术和下游生物工艺设备的进步。这种转变不仅限于生物工艺设备。在此贡献中,将讨论SUT如何快速转变生物过程及其运行设施的摘要,包括通过高细胞密度灌注和连续生物制造过程实现SUT的生物过程强化。

更新日期:2018-10-05
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