A novel and efficient synthesis of Hantzsch 1,4-dihydropyridines through metal-free oxidative CC coupling process was described. The reaction between benzylic alcohols, 1,3-dicarbonyl compounds and ammonium hydroxide in the presence of HBr in DMSO at 75 °C led to afford 1,4-dihydropyridine in excellent yields. This protocol introduces the use of benzyl alcohols instead of aldehydes as a new modification of the Hantzsch reaction.

中文翻译：

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HBr和DMSO通过无金属氧化C C偶联高效合成Hantzsch 1,4-二氢吡啶

描述了一种通过无金属的氧化性C C偶联过程新型高效合成Hantzsch 1,4-二氢吡啶的方法。苄醇，1，3-二羰基化合物与氢氧化铵在HBr存在下于DMSO中于75°C进行反应，从而以极佳的收率得到1,4-二氢吡啶。该协议引入了使用苯甲醇代替醛作为Hantzsch反应的一种新方法。