Synergistic Cu/Pd Catalysis for Enantioselective Allylation of Ketimine Esters: The Direct Synthesis of α‐Substituted α‐Amino Acids and 2H‐Pyrrols,Advanced Synthesis & Catalysis

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Synergistic Cu/Pd Catalysis for Enantioselective Allylation of Ketimine Esters: The Direct Synthesis of α‐Substituted α‐Amino Acids and 2H‐Pyrrols
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-10-30 , DOI: 10.1002/adsc.201800986
Liang Wei ₁ , Lu Xiao ₁ , Chun-Jiang Wang _{1,

2}

Affiliation

An efficient synergistic Cu/Pd catalyzed enantioselective α‐allylation of acyclic ketimine esters has been reported, which provides an entry to nonproteinogenic α‐allyl α‐amino acids in high yield, exclusive regioselectivity, and excellent enantioselectivity. Moreover, the more challenging cyclic ketimine ester could also be employed as a nucleophile for the construction of 3,4‐dihydro‐2H‐pyrrole derivatives bearing a quaternary stereogenic center using the same catalytic system.

中文翻译：

铜/钯协同催化Ketimine酯的对映选择性烯丙基化：α-取代的α-氨基酸和2H-吡咯的直接合成

据报道，一种有效的铜/钯协同催化的无环酮亚胺酯的对映选择性α-烯丙基化反应，为非蛋白来源的α-烯丙基α-氨基酸提供了高收率，排他性区域选择性和出色的对映选择性的入口。此外，更具挑战性的环状酮亚胺酯也可以用作亲核试剂，使用相同的催化系统构建带有季立体中心的3,4-二氢-2 H-吡咯衍生物。

更新日期：2018-10-30

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