Chemical-stimuli-responsive nanotherapeutics have gained great interest in drug delivery and diagnosis applications. These nanotherapeutics are designed to respond to specific internal stimuli including pH, ionic strength, redox, reactive oxygen species, glucose, enzymes, ATP and hypoxia for site-specific and responsive or triggered release of payloads and/or biomarker detections. This review systematically and comprehensively addresses up-to-date technological and design strategies, and challenges nanomaterials to be used for triggered release and sensing in response to chemical stimuli.

中文翻译：

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化学刺激响应可编程纳米治疗的设计策略。


化学刺激响应纳米疗法在药物输送和诊断应用中引起了极大的兴趣。这些纳米疗法旨在响应特定的内部刺激，包括 pH、离子强度、氧化还原、活性氧、葡萄糖、酶、ATP 和缺氧，以实现有效负载和/或生物标志物检测的位点特异性和响应性或触发释放。本综述系统、全面地讨论了最新的技术和设计策略，并对用于响应化学刺激的触发释放和传感的纳米材料提出了挑战。