Background

The proliferative phase of infantile hemangiomas (IHs) is usually complete by 9 months of life. Late growth beyond age 3 years is rarely reported.

Objective

To describe the demographic and clinic characteristics of a cohort of patients with late growth of IH, defined as growth in a patient >3 years of age.

Methods

A multicenter, retrospective cohort study.

Results

In total, 59 patients, 85% of which were female, met the inclusion criteria. The mean first episode of late growth was 4.3 (range 3-8.5) years. Head and neck location (55/59; 93%) and presence of deep hemangioma (52/59; 88%) were common characteristics. Posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities (PHACE) syndrome was noted in 20 of 38 (53%) children with segmental facial IH. Systemic therapy (corticosteroid or β-blocker) was given during infancy in 58 of 59 (98%) and 24 of 59 (41%) received systemic therapy (β-blockers) for late IH growth.

Limitations

The retrospective nature and ascertainment by investigator recall are limitations of the study.

Conclusion

Late IH growth can occur in children after 3 years of age. Risk factors include head and neck location, segmental morphology, and involvement of deep dermal/subcutaneous tissues.

中文翻译：

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3岁以上儿童婴儿血管瘤的晚期生长：一项回顾性研究

背景

婴儿血管瘤 (IH) 的增殖期通常在 9 个月大时完成。很少报道超过 3 岁的晚期生长。

客观的

描述一组晚期生长 IH 患者的人口统计学和临床​​特征，定义为患者年龄大于 3 岁。

方法

一项多中心、回顾性队列研究。

结果

总共有 59 名患者，其中 85% 为女性，符合纳入标准。晚期生长的平均第一次发作为 4.3（范围 3-8.5）年。头颈部位置 (55/59; 93%) 和深部血管瘤 (52/59; 88%) 是常见特征。P osterior窝畸形，ħ emangiomas，一个rterial异常，Ç ardiac缺陷，È叶异常（PHACE）综合征中38 20（53％）的儿童节段性面部IH指出。59 人中的 58 人 (98%) 和 59 人中的 24 人 (41%) 在婴儿期接受全身治疗（皮质类固醇或 β 受体阻滞剂）以治疗晚期 IH 生长。

限制

研究人员召回的回顾性性质和确定性是研究的局限性。

结论

3 岁以后的儿童可能会出现晚期 IH 生长。危险因素包括头颈部位置、节段形态和深部真皮/皮下组织受累。