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Dual-Stimuli Responsive Bismuth Nanoraspberries for Multimodal Imaging and Combined Cancer Therapy
Nano Letters ( IF 9.6 ) Pub Date : 2018-10-05 00:00:00 , DOI: 10.1021/acs.nanolett.8b02639
Zhenglin Li 1, 2, 3 , Ying Hu 4 , Zhaohua Miao 5 , Han Xu 6 , Chunxiao Li 6 , Yan Zhao 2 , Zhuo Li 1 , Manli Chang 7 , Zhuo Ma 4 , Ye Sun 2 , Flemming Besenbacher 3 , Peng Huang 6 , Miao Yu 1
Affiliation  

Development of stimuli-responsive theranostics is of great importance for precise cancer diagnosis and treatment. Herein, bovine serum albumin (BSA) modified bismuth nanoraspberries (Bi-BSA NRs) are developed as cancer theranostic agents for multimodal imaging and chemo-photothermal combination therapy. The Bi-BSA NRs are synthesized in aqueous phase via a facile reduction method using Bi2O3 nanospheres as the sacrificial template. The morphology, biocompatibility, photothermal effect, drug loading/releasing abilities, chemotherapy effect, synergistic chemo-photothermal therapy efficacy, and multimodal imaging capacities of Bi-BSA NRs have been investigated. The results show that the NRs possess multiple unique features including (i) raspberry-like morphology with high specific surface area (∼52.24 m2·g–1) and large cavity (total pore volume ∼0.30 cm3·g–1), promising high drug loading capacity (∼69 wt %); (ii) dual-stimuli responsive drug release, triggered by acidic pH and NIR laser irradiation; (iii) infrared thermal (IRT), photoacoustic (PA) and X-ray computed tomography (CT) trimodality imaging with the CT contrast enhanced efficiency as high as ∼66.7 HU·mL·mg–1; (iv) 100% tumor elimination through the combination chemo-photothermal therapy. Our work highlights the great potentials of Bi-BSA NRs as a versatile theranostics for multimodal imaging and combination therapy.

中文翻译:

用于多模式成像和癌症联合治疗的双刺激响应性铋纳米果莓。

刺激响应治疗学的发展对精确的癌症诊断和治疗非常重要。本文中,牛血清白蛋白(BSA)修饰的铋纳米树莓(Bi-BSA NRs)被开发为用于多峰成像和化学-光热联合疗法的癌症治疗剂。Bi-BSA NRs通过使用Bi 2 O 3的简便还原法在水相中合成纳米球作为牺牲模板。研究了Bi-BSA NRs的形态,生物相容性,光热效应,载药/释放能力,化学疗法作用,协同化学光热疗法功效以及多峰成像能力。结果表明,天然橡胶具有多种独特特征,包括(i)具有高比表面积(〜52.24 m 2 ·g –1)和大空腔(总孔体积〜0.30 cm 3 ·g –1)的覆盆子状形态。),有望实现高载药量(〜69 wt%); (ii)由酸性pH和NIR激光照射触发的双重刺激反应性药物释放;(iii)红外热(IRT),光声(PA)和X射线计算机断层摄影(CT)三峰成像,CT对比增强了高达〜66.7 HU·mL·mg –1的效率;(iv)通过化学-光热疗法的组合可100%消除肿瘤。我们的工作强调了Bi-BSA NRs作为多模态成像和联合治疗的多功能治疗学的巨大潜力。
更新日期:2018-10-05
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