Centre for Surface Chemistry and Catalysis KU Leuven, Celestijnenlaan 200F; 3001 Leuven Belgium
Department of Chemical and Energy Technology, ESCET; Rey Juan Carlos University, C/Tulipan s/n; 28933 Móstoles Spain
The inside cover picture, provided by Cirujano and co‐workers, illustrates the results of their work on recycling catalytic amounts of Pd(OAc)2 in the presence of redox active, stable and reusable metal‐organic microporous frameworks (MOF‐74), thus achieving the C−H functionalization of pharmaceutically interesting aza‐heterocycles with alkenes. This is the first time that redox/acid active sites in the porous, non‐toxic and earth abundant robust MOF‐74 platform are used to avoid the fast deactivation of the cationic Pd species during the room temperature and ambient pressure alkenylation of indoles and uracils under batch and continuous flow conditions. Details can be found in the communication on pages xxxx–xxxx (F. G. Cirujano, P. Leo, J. Vercammen, S. Smolders, G. Orcajo, D. E. De Vos, Adv. Synth. Catal. 2018, 360, xxxx–xxxx; DOI: 10.1002/adsc.201800817)
中文翻译：
MOF延长了Pd（II）催化剂在烯胺类芳烃的室温烯基化反应中的寿命
所述内封面图片，通过Cirujano和同事提供，示出了在循环催化量的Pd（OAC）的其工作成果2在具有氧化还原活性，稳定且可重复使用的金属有机微孔框架（MOF-74）的存在下，从而实现了具有药用意义的氮杂杂环在医药方面的CH功能化。这是首次在多孔，无毒且富含泥土的坚固MOF-74平台上使用氧化还原/酸活性位点，以避免在室温和环境压力下吲哚和尿嘧啶烯基化过程中阳离子Pd物种的快速失活。在间歇和连续流动条件下。细节可以在网页上为xxxx-xxxx（F. G. Cirujano，P.利奥，J.佛卡门，S.闷烧，G.奥尔卡霍，D.E。德沃思，通信中找到。进阶Synth的CATAL。2018，360，为xxxx-xxxx; DOI：10.1002 / adsc.201800817）
京公网安备 11010802027423号