Introduction: Our study aimed to analyze the prognostic implication of the multiplicity of solid portions in part‐solid nodules (PSNs) on computed tomography scans and compare the prognostic performance of various measures of solid portions, including the single largest solid portion, solid proportion, and summated multiple solid portion measurements. Methods: The cases of a total of 345 patients with surgically resected stage IA adenocarcinomas manifesting as PSNs were retrospectively reviewed. The multiplicity of the solid portion in PSNs was determined and the diameter of each solid portion was measured. The prognostic implication of the multiplicity of the solid portion and other clinical variables in relation to disease‐free survival (DFS) was analyzed by using Cox regression. In addition, risk stratification based on the single largest solid portion, sum of the solid portions, single solid proportion, and sum of the solid proportions was conducted. Next, concordance indices (C‐indices) for DFS were obtained for each measure and compared. Intrareader and interreader measurement variability was assessed. Results: Multiplicity of the solid portion did not have a significant effect on DFS; clinical T category was the only independent risk factor for tumor recurrence (p < 0.05). The C‐index of the single solid portion (conventional clinical T category) was 0.817 (95% confidence interval: 0.691–0.942). There were no significant differences (p > 0.05) between the C‐indices of the single solid portion and other solid portion measures. Interreader measurement variability was substantial. Conclusions: The current clinical T categorization of PSNs based on the single solid portion measurement is appropriate.

中文翻译：

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用于 T 分类的部分实性结节中多个实性部分的测量：预后意义的评估

简介：我们的研究旨在分析部分实体结节 (PSN) 中实体部分的多样性对计算机断层扫描的预后影响，并比较实体部分的各种测量的预后性能，包括单个最大实体部分、实体比例、并总结了多个固体部分的测量值。方法：对 345 例手术切除的 IA 期腺癌患者的病例进行回顾性分析。确定了 PSN 中固体部分的多样性，并测量了每个固体部分的直径。使用 Cox 回归分析实体部分的多样性和与无病生存 (DFS) 相关的其他临床变量的预后意义。此外，进行了基于单个最大固体部分、固体部分总和、单一固体比例和固体比例总和的风险分层。接下来，为每个测量获得 DFS 的一致性指数（C 指数）并进行比较。评估了阅读器内和阅读器间测量的可变性。结果：固体部分的多样性对 DFS 没有显着影响；临床 T 类别是肿瘤复发的唯一独立危险因素（p < 0.05）。单一固体部分（常规临床 T 类别）的 C 指数为 0.817（95% 置信区间：0.691-0.942）。单一固体部分和其他固体部分的 C 指数之间没有显着差异 (p > 0.05)。阅读器间测量变异性很大。结论：